Enalapril Adverse Reaction, Pharmacogenomics, Stroke
Conditions
Brief summary
Dry cough is the most common adverse reaction of angiotensin converting enzyme, including enalapril, in Chinese population. Clinical observations suggest that the incidence of ACEI-induced dry cough is different between Chinese and other racial groups, however, there is still lack of research data in Chinese. Stroke is the second leading cause of death in the world and leading cause of death in China. Except the known risk factor such as hypertension, high homocysteine level, folic acid deficiency, the impact of genetics should not be ignored. In this study, we will investigate whether there are specific genotypes which may predict the incidence of (1)enalapril-induced dry cough in Chinese and (2)first stroke in hypertensive patients taking enalapril or enalapril-folic acid therapy, so as to provide a basis for developing guidelines on precision medication in enalapril therapy apply to Chinese population.
Interventions
GENETICdetection of genotype
detection of genotype by next generation sequencing
Sponsors
Cui Yimin
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients taking enalapril or enalapril-folic acid therapy * Signed informed consent.
Exclusion criteria
* Patients not taking enalapril treated * Intolerance or unwillingness to blood sample collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of dry cough | At 2 years |
| First Incidence of stroke | At 2 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Genotype detected by next generation sequencing | pre-dose of enalapril or enalapril-folic acid (Baseline) | Collect blood specimen before enalapril administration, then detect genotype of enalapril by next generation sequencing. |
Countries
China
Contacts
Primary ContactQian Xiang, Ph.D
Outcome results
None listed