Sarcopenia
Conditions
Keywords
elderly, sarcopenia, strengthening exercise
Brief summary
As the proportion of older adults increases, elderly-related issues attract more attention. Sarcopenia is one of the popular elderly-related issues. Sarcopenia may induce decreased muscle strength, poor physical activity, even disability and increase rate of hospitalization and mortality. Therefore, we want to figure out the management for decreasing prevalence of sarcopenia in older adults. This trial is planned to perform during 2017/08/01\ 2017/12/31. We plan to enroll 60 elderlies who are sarcopenia. These patient will be divided into 2 group randomize. Experimental group will be received a set of exercise, composed by warm-up, strengthening training with a towel, cold-down, 60 minutes per time, 3 times per week. Control group will be suggested home-based walking activity. We will evaluate the patient's functional performance three times, before training, after training, post-training for three months, respectively. These results will be analyzed by repeated measure ANOVA.
Detailed description
As the proportion of older adults increases, elderly-related issues attract more attention. Sarcopenia is one of the popular elderly-related issues. Skeletal muscle is an important component for sustaining physical activity and storing protein. Protein of skeletal muscle is used as energy substrates in cases of starvation or under stress. As being aging, physical condition degenerates gradually. Older adults usually have multiple chronic diseases. Lesser physical function results in less physical activity. As a result, more muscle mass would be lost. In previous study, after the age of 50 year-old, muscle mass decreases 1-2% per year. The velocity of muscle mass decline increases after the age of 60 year-old. Sarcopenia may induce decreased muscle strength, poor physical activity, even disability and increase rate of hospitalization and mortality. Therefore, we want to figure out the management for decreasing prevalence of sarcopenia in older adults. Exercise is an important method for preventing sarcopenia. In this study, we intend to design a set of exercise which is easily performed for older adults and also has preventing muscle mass loss effect. Towel is an important tool for exercise. Duration to execute is during 2017/08/01\ 2017/12/31. We randomize these 60 older adults into 2 groups (experimental group and control group) and there are 30 older adults in each group. Those older adults are age above 65 year-old, have lower grip strength and slower walking speed. One assistant who doesn't know which group these older adults belonged to would record their basic information and is responsible for the evaluation. We will evaluate the older adults' functional performance three times, before training, after training, post-training for three months, respectively.
Interventions
PROCEDUREExercise with a towel
Exercise program composes with warm-up, strengthening exercise, cold-down, 60 minutes/time, 3 times/week. A towel is an important tool for exercise. Total duration of the program is 3 months.
PROCEDUREHome-based exercise
Home-based program focuses on walking activity at fast speed, 3 times/week, 60 minutes/times. The total duration is 3 months.
Sponsors
Chang Gung Memorial Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
The assistant who doesn't know the group which patients belong to will evaluate the functional performance of the patients three times, such as before training, after training, post-training 3 months.
Intervention model description
We randomize these 60 older adults into 2 groups (experimental group and control group) and there are 30 older adults in each group. Those older adults are age above 65 year-old, have lower grip strength and slower walking speed. Experimental group receive this exercise program training, 60 minutes/time, 3 times/week, total duration: 3 months. Home-based program focuses on walking activity at fast speed, 3 times/week, 60 minutes/times, would be assigned for Control group. Total duration is 3 months.
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. age above 65 y/o 2. low muscle mass (male\<7.0 kg/m2, female\<5.4kg/m2, tested by Dual energy X-ray Absorptiometry) 3. with or without low grip strength (male\< 26 kg, female \<18 kg) 4. with or without low walk speed (≤ 0.8 m/s).
Exclusion criteria
1. cognitive impairment or can't follow order appropriately 2. elderlies with medical problems that they can't perform the exercise program
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Berg balance test | Baseline | The investigator record scores of 14 items involved in Berg balance test for measuring balance of the old adults. |
| Fat mass | Baseline | Dual-energy X-ray absorptiometry is used for measuring fat mass. |
| Fat-free mass | Baseline | Dual-energy X-ray absorptiometry is used for measuring fat-free mass. |
| Bone mineral density | Baseline | Dual-energy X-ray absorptiometry is used for measuring bone mineral density. |
| Maximal grip strength | Baseline | Handgrip dynamometer is used for measuring maximal grip strength. |
| Walking speed | Baseline | Participants are asked to walk at a comfortable speed to perform 10 meter walk test. |
| Timed up and go test | Baseline | At first, the participant sits down. Then the participant would be asked to stand up, walk straight for 3 meters, turn around, go back to the chair and sit down. The duration of whole test would be measured. |
| Times of stand-up and sit-down within 30 seconds | Baseline | The participant is asked to cross arm before the chest. The investigator would record the times of stand-up and sit-down within 30 seconds. |
| 6 minutes walking test | Baseline | At first, the participant sits down for a rest for 10 minutes. The participant would be asked to walk as longer distance as the participant can within 6 minutes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fat mass | Change between baseline and 3 month after training | Dual-energy X-ray absorptiometry is used for measuring fat mass |
| Fat-free mass | Change between baseline and 3 month after training | Dual-energy X-ray absorptiometry is used for measuring fat-free mass |
| Bone mineral density | Change between baseline and 3 month after training | Dual-energy X-ray absorptiometry is used for measuring bone mineral density |
| Maximal grip strength | Change between baseline and 3 month after training | Handgrip dynamometer is used for measuring maximal grip strength. |
| Walking speed | Change between baseline and 3 month after training | Participants are asked to walk at a comfortable speed to perform 10 meter walk test. |
| Timed up and go test | Change between baseline and 3 month after training | At first, the participant sits down. Then the participant would be asked to stand up, walk straight for 3 meters, turn around, go back to the chair and sit down. The duration of whole test would be measured. |
| Times of stand-up and sit-down within 30 seconds | Change between baseline and 3 month after training | The participant is asked to cross arm before the chest. The investigator would record the times of stand-up and sitdown within 30 seconds. |
| 6 minutes walking test | Change between baseline and 3 month after training | At first, the participant sits down for a rest for 10 minutes. The participant would be asked to walk as longer distance as the participant can within 6 minutes. |
| Berg balance test | Change between baseline and 3 month after training | The investigator record scores of 14 items involved in Berg balance test for measuring balance of the old adults. |
Countries
Taiwan
Outcome results
None listed