Infertility, Female, Mayer Rokitansky Kuster Hauser Syndrome
Conditions
Keywords
Infertility, female, Mayer Rokitansky Kuster Hauser Syndrome, Transplantation; Deceased donor
Brief summary
Uterus transplantation: screening, in vitro fertilization \[IVF\] treatment to be able to freeze embryos, uterus transplantation, pregnancy and afterwards removal of the uterus.
Interventions
PROCEDUREuterus transplantation
transplantation of a uterus from a deceased donor
Sponsors
University Hospital, Ghent
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
* Female with Maier-Rokitansky-Kuster-Hauser syndrome * Mucosal neovagina of at least 7 cm * In a stable relationship for at least 1 year * Child wish * Good renal function (and presence of both kidneys) * Psychologically stable and compliant * At least 8 frozen embryos after IVF/intracytoplasmic sperm injection \[ICSI\] * Living in Belgium and a good health insurance * Willing and able to provide informed consent
Exclusion criteria
* Major pelvic surgery * Major chronic illnesses * Other risk factors or malignancies * BMI \> 30
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival of the uterus 1 year after transplantation | 1 year after uterus transplantation | Survival of the uterus 1 year after transplantation |
| Complications after uterus transplantation | As long as the uterus remains in situ (the uterus will be removed within one year after delivery) | Complications after uterus transplantation |
| Ongoing pregnancy rate | 4 weeks after embryo transfer | Ongoing pregnancy rate |
| Take home baby rate | 9 months after embryo transfer | Take home baby rate |
Countries
Belgium
Contacts
Primary ContactSteven Weyers, MD, PhD
Backup ContactSara Somers, MSc
Outcome results
None listed