Neonatal Infection, Premature Rupture of Membrane
Conditions
Brief summary
This study hypothesizes that early-onset neonatal Infections are related to premature rupture of membrane (PROM) and that early intervention can improve the prognosis of newborns. The objective of this study is to analyze the correlation between PROM and early-onset neonatal infections and to assess the prognosis of newborns. A cohort study is designed to implement the study. The subjects of study group are pregnant women who are diagnosed as PROM or chorioamnionitis and whose gestational age is ≥ 24 weeks. The subjects of control group are pregnant women without PROM and chorioamnionitis. Control group and research group are paired at 1: 1 ratio. The main contents of the study include three aspects. (1) The correlation between PROM and chorioamnionitis. (2) The correlation between PROM and early-onset neonatal infections. (3) The pathogenesis of intrauterine infection and neonatal infection.
Interventions
None listed
Sponsors
Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Chengdu Women's and Children's Central Hospital
Shenzhen Maternity & Child Healthcare Hospital
Nanjing Maternity and Child Health Care Hospital
Shenzhen Bao'an Maternal and Child Health Hospital
Second Hospital of Jilin University
Bayi Children's Hospital Affiliated to PLA Army General Hospital, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* PROM or chorioamnionitis * gestational age is ≥ 24 weeks
Exclusion criteria
* gestational age \<24 weeks * artificial rupture of membrane for labor induction * natural rupture of membrane during induction before labor
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of early-onset neonatal infections | 7 days after birth | The incidence of early-onset neonatal infections will be compared between study group and control group. |
Countries
China
Outcome results
None listed