Lung Cancer
Conditions
Keywords
Lung cancer, diagnosis, volatile organic compounds
Brief summary
Determination of volatile organic compounds to discriminate patients with lung cancer from healthy smokers and non-smokers healthy subjects.
Interventions
DEVICECollection of volatile organic compounds during exhalation
The volatile organic compounds (VOCs) are collected in sorbents at rest and at the end of exhalation according to the concentration of carbon dioxide using ReCIVA breath sampler. The identification of the VOCs will be done by chromatography (Gas Chromatography Mass Spectrometry GC-MS)
Sponsors
Institut National de Recherche en Informatique et en Automatique
Institut Pasteur de Lille
Institut MinesTelecom (IMT)
University Hospital, Lille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with histologically proven lung cancer Controls: * healthy smoker or non-smoker subjects * without respiratory diseases excepted chronic obstructive pulmonary disease.
Exclusion criteria
* history of cancer other than lung cancer within 5 years before inclusion * oral or facial malformation * incomprehension of maneuvers for the collection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Discriminating power of VOCs | 34 months | Discriminating power of VOCs using discriminant analyzes using innovative data mining methods based on multi-objective combinatorial optimization. |
Countries
France
Outcome results
None listed