Bipolar Affective Disorder
Conditions
Keywords
Bipolar affective disorders, Cognition, Emotion, Embodiment, Sensorimotor, Simulation
Brief summary
Based in an embodied approach of cognition, several studies have highlighted a direct link between perception of an object or an emotion and the associated motor responses. This study investigated in patients suffering from bipolar affective disorders whether the perception of emotional words involves an automatic sensorimotor simulation of approach and avoidance behaviors, and whether the perception of an object involves an automatic sensorimotor simulation of object prehension (affordance). We hypothesize that, in this pathology, low level (sensorimotor) cognitive processes are preserved whereas high-level (attentional) are altered. 20 patients suffering from bipolar affective disorders and 20 healthy controls will be recruited. The main objective is the emergence of sensorimotor compatibility effects in approach-avoidance task with emotional stimuli (gain between compatible vs incompatible conditions).
Interventions
BEHAVIORALcognitive tasks + IQ + MINI
Patients will perform different tasks: * cognitive tasks : reaction time (Alert TEA, Zimmermann and Fimm, 2005) + Edinburgh laterality questionnaire (Oldfield,1971) + hamilton and young's scale (Tohen et al., 2009) + Montreal Cognitive Assessment (MoCA) (Nasreddine et al., 2005) + experimental task (approach/ avoidance and affordance task). * Intelligence Quotient (IQ) test (PM38, Raven, 1960) * Mini International Neuropsychiatric Interview (MINI, Van Vliet et al., 2006)
BEHAVIORALcognitive tasks
Healthy volunteers will perform only the cognitive tasks = reaction time alert TEA, Zimmermann and Fimm, 2005 + Edinburgh laterality questionnaire (Oldfield, 1971) + experimental task (approach/ avoidance and affordance task).
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
For patients: * Affiliated or entitled to a social security * Aged between 18 and 55 * Patients of both sexes suffering from bipolar disorders (DSM V criteria) whatever the subtype * Stabilized from a point of view clinical and therapeutic * Euthymic (score \<7 at the Hamilton scale, and score \<8 at Young's scale) * Must have given their informed consent before their participation in the study * Be right-handed (score\> 14 on the laterality scale) For control group: * Affiliated or entitled to a social security * Must have given their informed consent before their participation in the study * Be right-handed (score\> 14 on the lateral scale) * Aged 18 to 55 matched by age (± 5 years), sex, and on the study level of patients (years of schooling after primary school ± 2 years)
Exclusion criteria
For patients: * Thymic acute decompensation * Hamilton scale \> 8, Young's scale \> 9 * Montreal Cognitive Assessment (MOCA) \<26 * History neurological pathology with cerebral impairment or serious somatic disease * Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal) within 6 months. * IQ \< 70 * History of head trauma For control group: * History of head trauma * Neurological pathology with cerebral impairment or serious somatic disease * Psychotropic treatment * Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal) * IQ \< 70
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| response time for avoidance and affordance task | Months 24 | Comparison of response time for avoidance and affordance task between patients and healthy volunteers. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| response time for affordance task | Months 24 | Comparison of response time for affordance task between patients and healthy volunteers. |
| correlations with age at onset of the disease, the number of thymic decompensations and the existence of psychotic symptoms | Months 24 | These informations were collected of the medical file. |
| response time and cognitive tests | Months 24 | Correlation between response time and cognitive tests of patients and healthy volunteers. |
Countries
France
Outcome results
None listed