Arterial Occlusive Diseases
Conditions
Brief summary
Color coded blood flow and blood perfusion techniques are applied to the endovascular treatment of infrapopliteal arterial occlusion,to establish a method of quantitative evaluation of blood flow and tissue perfusion,to improve the level of calculation of condition and curative effect. So as to establish a new complete evaluation system of infrapopliteal arterial occlusive disease, to guide clinical further. At the same time establish a digital information platform for clinical, lay the foundation for the large research.
Interventions
RADIATIONdyna-pbv
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients are diagnosed as lower limb atherosclerosis occlusion from June 2016 to June 2018 in our centre; 2. All participating patients provided written informed consent and willing to participate; 3. aged 40 years and more; 4. the class of lower ischemia is upon 4; 5. below-the-knee arteries stenosis or occlusion is indicated by duplex or computed tomographic angiography; 6. there is no heavy stenosis in superficial femoral artery (stenosis\<30%), or short length lesion(length≤5cm, stenosis≥30%); 7. infection or ulceration don't happen in the area of surgery; 8. below the inguinal ligament arteries don't have the history of bypass or interventional surgery.
Exclusion criteria
1. disagree and refuse to the free therapy; 2. lesion length of superior artery is more than 5cm; 3. history of heart dysfunction: congestive heart failure,, myocardial infarction, severe arrhythmia; 4. With severe metabolic disease, renal impairment(serum creatinine\>1.4mg/dL, glomerular filtration rate\<60) affect the excretion of contrast agents; 5. have the diseases or agents which will reduce the viable of data; 6. allergy to iodinated contrast medium.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| patency rate | 1 year | We compare the change of blood flow velocity and blood perfusion volume before and after the recanalization of infrapopliteal arteries to assess the initial patency rate. While we test the ankle brachial index and toe brachial index at 3 , 6, 12 months, lower extremity arterial ultrasound at 6 mouths and computed tomographic angiography in 1 year to evaluate the patency of one year. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| wound healing rate | 1 year | This is to evaluate the prognosis of patients who with the foot ulcer. |
Countries
China
Contacts
Primary ContactBao Liu, Ph.D
Outcome results
None listed