Multiple Sclerosis
Conditions
Keywords
Multiple sclerosis, anesthesia
Brief summary
Aim of the retrospective study was to evaluate the influence of the labour on the clinical course of the parturients with MS in selected 6 month follow-up interval and to evaluate to possible influence of the different anesthesia/analgesia types on the course of MS.
Detailed description
The role of anesthesia in multiple sclerosis (MS) progression remains unclear in spite of few foreign studies. The most frequently afflicted patients by MS are women of childbearing age and influence of anesthesia or obstetric epidural analgesia has only not been investigated in Czech Republic. The study aims to retrospectively compare the further course of the disease of MS in patients who labor between 2004 and 2013 in University Hospital Brno either by caesarean section or vaginally with epidural analgesia , with patients who gave birth spontaneously without anesthesia.The aim of the study was to evaluate the influence of the labour on the clinical course of MS and further evaluate the possible influence of the type of anesthesia/analgesia in the peripartal period on the MS progression.
Interventions
OTHERData search
Patients data were searched for the patients with MS, who laboured in tertiary perinatology center in the study period
Sponsors
Masaryk University
Brno University Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Inclusion criteria
* Parturients with multiple sclerosis * Possible follow up - neurologic examination available after 10 month from delivery
Exclusion criteria
* probable or no multiple sclerosis at time of labor * unknown neurology history * unknown data on neurology outcome 6 months after labour * Incomplete data * Follow-up not possible
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Multiple sclerosis decompensation/progression at 3rd month | 3 months after labour | Relapse occurence from labour to 3 months, after delivery was recorded. A relapse was defined as the appearance or worsening of symptoms of neurologic dysfunction lasting more than 24 hours, new lesions on MRI or need of reinforcement in treatment. For disease state after delivery we used dichotomic approach: relapse (at least one) or no relapses. |
| Multiple sclerosis decompensation/progression | 3 months after labour | Relapse occurence from labour to 6 months after delivery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MS progression and the type of anesthetic method | 6 months after labour | MS progression comparison due to the type of anethesia |
Countries
Czechia
Outcome results
None listed