Testing How Well Magnesium Citrate Capsules Work as Preparation for a Colonoscopy

Efficacy of Magnesium Citrate Capsules in Colonoscopy Preparation: A Randomized, Investigator-blinded Non-inferiority Trial Using Polyethylene Glycol as the Active Control.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03247595

Enrollment

Registered

2017-08-11

Start date

2017-09-26

Completion date

2020-06-16

Last updated

2021-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colonoscopy

Keywords

Colonoscopy preparation, Magnesium Citrate Capsules

Brief summary

This study compares a colonoscopy preparation composed of magnesium citrate capsules to a preparation of polyethylene glycol solution. The hypothesis is that the magnesium citrate capsules work as well and are better liked by patients due to the lack of taste.

Interventions

DIETARY_SUPPLEMENTMagnesium Citrate Capsules

36 magnesium citrate gelatin capsules

OTHERPolyethylene Glycol 3350

4 liters of Polyethylene Glycol for colonoscopy preparation

OTHERDulcolax Tablets

4 Dulcolox Tablets

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

SINGLE (Investigator)

Masking description

The endoscopist who reports colon cleanliness is blinded to the subject's assignment.

Intervention model description

One arm receives Polyethelyne Glycol colonoscopy preparation and the other arm receives magnesium citrate capsules colonoscopy preparation.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* • Scheduled for colonoscopy at Sinai Hospital or Woodholme GI Associates

Exclusion criteria

* • Calculated creatinine clearance under 30ml/min * On PPI and unable to stop for five days before colonoscopy * On H2 blockers and unable to stop for two days before colonoscopy * achlorhydria * Previous colon surgery * Cardiovascular disease, including uncontrolled congestive heart failure, unstable angina pectoris, or recent (3 months) percutaneous transluminal coronary angioplasty, myocardial infarction, or coronary artery bypass graft surgery * Colon disease, including chronic constipation (\<2 bowel movements per week for \>1 year), ileus and/or acute obstruction, ileostomy, right or transverse colostomy, subtotal colectomy (≥50% of colon removed) with ileosigmoidostomy, hypomotility syndrome, megacolon, or idiopathic pseudo-obstruction * Pregnant women

Design outcomes

Primary

Measure	Time frame	Description
Colon Cleanliness	During colonoscopy	Boston scale rating of colon cleanliness

Secondary

Measure	Time frame	Description
Patient compliance and satisfaction	On the day of colonoscopy	Patient's experience recorded in a questionnaire

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026