Chinese Observational Prospective Study of Aging Population With Chronic Kidney Disease(C-OPTION)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03246204

Enrollment

3000

Registered

2017-08-11

Start date

2017-08-31

Completion date

2023-02-28

Last updated

2017-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease

Brief summary

The study is an observational, multicenter, prospective cohort study aimed at evaluating a 5-year screening programme for chronic kidney disease(CKD) in a population of elderly patients, aged 65 years or more, in China.To analyze the etiology and composition spectrum, the incidence of complications and co-morbidities.To assess the correlation between daily living ability, mental and physical function, quality of life, nutritional status and prognosis.To develop biomarkers of renal aging.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* age≥65 years * clinical diagnosis of CKD * signed informed consent

Exclusion criteria

* subjects who have a poor compliance and cannot be scheduled for follow-up * subjects participating in other interventional clinical trials * ESRD or dialysis * Acute kidney injury(AKI) * history of solid organ or bone marrow transplantation * active malignancy within 24 months prior to screening or metastatic cancer * life expectancy less than 6 months； * severe cognitive impairment（NYHA III or IV） * HIV infection or AIDS * subjects cannot be able to complete the assessment including dementia or other mental disorders, limited physical activity, severe visual impairment * simple hematuria

Design outcomes

Primary

Measure	Time frame	Description
Death	5 year	—
Incidence of End Stage Renal Disease (ESRD)	5 year	ESRD will be defined as estimated glomerular filtration rate(eGFR)\<15 mL/min/1.73 m2 or dialysis
eGFR decline≥40%	5 year	—

Secondary

Measure	Time frame
Acute coronary syndrome	5 year
Peripheral arterial disease	5 year
Heart failure	5 year
Cerebral stroke	5 year

Contacts

Primary Contactguangyan cai

caiguangyan@sina.com00861066935462

Backup Contactshuang liang

liangshuang301@163.com008615110246423

Outcome results