Bone Healing Study

Study of the Granulation Tissue Formation in the Early Fracture Hematoma

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03244969

Enrollment

Registered

2017-08-10

Start date

2017-08-01

Completion date

2017-11-30

Last updated

2021-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Fracture

Keywords

Hematoma fracture, angiogenesis, bone formation

Brief summary

The aim of the research is to identify structural tissue changes in the early fracture hematomas.

Detailed description

The fracture hematomas obtained during reconstructive bone surgery from patients with bone fractures will be examined. Histological methods and ultra-thin sections for electron microscopy will be used to identify structural tissue changes in the granulation tissue in different period of time after bone fracture. Immunohistochemical analysis will be performed to estimate the dynamic of proliferation, differentiation and cell migration during granulation and reticulofibrosis bone tissues development.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 84 Years

Healthy volunteers

Inclusion criteria

* Patients with fractures of the upper and lower extremities * Patients for whom the surgical bone reconstruction are indicated

Design outcomes

Primary

Measure	Time frame
Granulation tissue formation	23 days

Countries

Russia

Outcome results