Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
Chronic obstructive pulmonary disease is a leading cause of mortality worldwide. It is a systemic disease which includes pulmonary, cardiac, muscular, digestive and cognitive impairments. Pulmonary rehabilitation is a symptomatic treatment to reduce dyspnea and functional incapacity. However, it effects on cognitive dysfunction are not well known. The aim of this study is to assess the effects of a comprehensive pulmonary rehabilitation program on cognitive dysfunction in patients with severe to very severe chronic obstructive pulmonary disease using the Montreal Cognitive Assessment tool.
Interventions
OTHERPulmonary rehabilitation
See group description.
Sponsors
CHU de Rouen - Accueil
Groupe Hospitalier du Havre
ADIR Association
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age \> 18years; * Chronic obstructive pulmonary disease stade III to IV; * Referred for pulmonary rehabilitation. Non Inclusion Criteria: * Pregnancy or likely to be; * History of psychiatric, neuro-vascular, cognitive disease or cranial trauma; * Active alcoholism; * Guardianship; * Hospitalisation for acute exacerbation of chronic obstructive pulmonary disease in the previous 4 weeks;
Exclusion criteria
* Interruption of the pulmonary rehabilitation program \> 15 days; * Disruption of the training before the 18th session; * Less than 18 sessions in four month.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Baseline cognitive function | Cognitive function is assessed at the beginning of the rehabilitation program : day 0 | Cognitive function is assessed with the Montreal Cognitive Assessement tool |
| Cognitive function after pulmonary rehabilitation | Cognitive function is assessed at the end of the rehabilitation program : day 60 | Cognitive function is assessed with the Montreal Cognitive Assessement tool |
| Cognitive function : follow up | Cognitive function is assessed 3 month after rehabilitation : day 150 | Cognitive function is assessed with the Montreal Cognitive Assessement tool |
| Change in cognitive function from baseline to the end of pulmonary rehabilitation | Change in cognitive function from baseline to the end of pulmonary rehabilitation is assessed with end of pulmonary rehabilitation minus baseline values (day 60 - day 0) | Cognitive function is assessed with the Montreal Cognitive Assessement tool |
| Change in cognitive function from the end of pulmonary rehabilitation to 3 month of follow up | Change in cognitive function from the end of pulmonary rehabilitation to 3 month of follow up is assessed with the 3 month of follow minus the end of pulmonary rehabilitation values (day 150 - day 60) | Cognitive function is assessed with the Montreal Cognitive Assessement tool |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life : baseline | Quality of life is assessed at the beginning of the rehabilitation program : day 0 | Quality of life is assessed using the Saint Georges Respiratory Questionnaire |
| Quality of life : end of pulmonary rehabilitation | Quality of life is assessed at the end of the rehabilitation program : day 60 | Quality of life is assessed using the Saint Georges Respiratory Questionnaire |
| Quality of life : follow-up | Quality of life is assessed 3 month after the end of the rehabilitation program : day 150 | Quality of life is assessed using the Saint Georges Respiratory Questionnaire |
| Functional capacity (six-minute walk test) : baseline | Functional capacity is assessed at the beginning of the rehabilitation program : day 0 | Functional capacity is assessed with the six-minute walk test |
| Functional capacity (six-minute stepper test) : end of pulmonary rehabilitation | Functional capacity is assessed at the end of the rehabilitation program : day 60 | Functional capacity is assessed with the six-minute stepper test |
| Relation between the cognitive function and the respiratory function (forced expiratory volume in 1 second) | The relation is assessed between baseline demographic data at day 0 | Cognitive function is assessed with the Montreal Cognitive Assessement tool and respiratory function is assessed with spirometric evaluation |
| Functional capacity (six-minute stepper test) : baseline | Functional capacity is assessed at the beginning of the rehabilitation program : day 0 | Functional capacity is assessed with the six-minute stepper test |
| Adherence | Adherence is assessed at the end of the rehabilitation program : day 60 | Adherence to the pulmonary rehabilitation program is assessed by the following equation : number of session performed divided by the number of scheduled sessions |
| Anxiety and depression : baseline | Anxiety and depression are assessed at the beginning of the rehabilitation program : day 0 | Anxiety and depression are assessed with the Hospital Anxiety and Depression scale (HAD). |
| Anxiety and depression : end of pulmonary rehabilitation | Anxiety and depression are assessed at the end of the rehabilitation program : day 60 | Anxiety and depression are assessed with the Hospital Anxiety and Depression scale (HAD). |
| Anxiety and depression : follow up | Anxiety and depression are assesses 3 month after the end of pulmonary rehabilitation program : day 150 | Anxiety and depression are assessed with the Hospital Anxiety and Depression scale (HAD). |
Countries
France
Outcome results
None listed