Chronic Obstructive Pulmonary Disease, Cor Pulmonale
Conditions
Keywords
Cor pulmonale, COPD, Malabsorption, D-xylose, Zinc
Brief summary
Aim: To investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to COPD patients without cor pulmonale potentially due to venous obstruction in the portal vein system. The presence of cor pulmonale was determined by echocardiography. The concentration of D-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. Furthermore, urine was collected for five hours to determine the amount of excreted D-xylose.
Detailed description
Background: Cor pulmonale is a common complication to Chronic Obstructive Pulmonary Disease (COPD), and may result in increased pressure in the inferior caval vein and stasis of the liver. The chronic pulmonary hypertension may lead to stasis in the veins from the small intestine and thereby compromise absorption of nutrients. Aim: To investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to COPD patients without cor pulmonale. Methods: Absorption of D-xylose (25 g) and zinc (132 mg), administered as a single dose, was tested in 14 COPD patients, seven with and seven without cor pulmonale. The presence of cor pulmonale was determined by echocardiography. The concentration of D-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. Furthermore, urine was collected for five hours to determine the amount of excreted D-xylose.
Interventions
DIAGNOSTIC_TESTAbsorption test with D-xylose and zink
Absorption of D-xylose (25 g) and zinc (132 mg), administered as a single dose. The concentration of D-xylose and zinc was measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. Furthermore, urine was collected for five hours to determine the amount of excreted D-xylose.
Sponsors
Jens Rikardt Andersen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
All patients had Chronic Obstructive Lung Disease. Those with additional Cor pulmonale was compared to those without
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* A diagnosis of COPD * Clinically stable = Unchanged medication for COPD for at least 6 months
Exclusion criteria
* Unable to understand Danish * Other clinically important heart-disease than chronic right heart changes presumably due to lung disease * Clinically significant gastro-intestinal or kidney disease * Diabetes * Treatment with corticosteroids for at least 6 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Absorption fraction of D-xylose | 3 hours | plasma concentration, mmol/l |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Absorption of zinc | 3 hours | plasma concentration, micromol/l |
| Absorption fraction of D-xylose | 5 hours | urine excretion, mmol |
Outcome results
None listed