High Definition Endoscopy and Virtual Chromoendoscopy Versus Standard Resolution Endoscopy in Detection of Colon Polyps

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03243669

Enrollment

2146

Registered

2017-08-09

Start date

2010-12-01

Completion date

2014-12-31

Last updated

2023-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colonic Adenoma

Keywords

Colonoscopy, High-definition endoscopy, Virtual chromoendoscopy, Adenoma detection rate (ADR)

Brief summary

Over the last years a number of new endoscopic imaging modalities have been introduced (high-definition and virtual chromoendoscopy). Given the theoretical advantage of these new imaging techniques, the investigators aimed to investigate their use for the detection of polyps during colonoscopy.

Interventions

DIAGNOSTIC_TESTHigh-definition

High-definition colonoscopy

DIAGNOSTIC_TESTVirtual chromoendoscopy

Virtual chromoendoscopy

DIAGNOSTIC_TESTStandard

Standard colonoscopy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* referred for colonoscopy * signed informed consent

Exclusion criteria

* subtotal colectomy * known colorectal tumor or polyp prior to colonoscopy * genetic predisposition to colon cancer namely FAP, HNPCC, Hyperplastic polyposis syndrome, juvenile polyposis, Peutz-Jeghers syndrome * inflammatory bowel disease * primary sclerosering cholangitis

Design outcomes

Primary

Measure	Time frame	Description
Adenoma detection rate (ADR)	7-10 days	Percentage of colonoscopies with detection of 1 or more adenomas. ADR is a well-established quality indicator in colonoscopy in the prevalence of adenomas detected (ADR) as recommended by American Society for Gastrointestinal Endoscopy (ASGE)/American College of Gastroenterology Task Force (ACGTF) and European Society of Gastrointestinal Endoscopy (ESGE). Guidelines stipulate to use ADR as main quality indicator in colonoscopy.

Secondary

Measure	Time frame	Description
Number of adenomas	7-10 days	Adenoma per colonoscopy rate (APCR)
Type of adenomas	7-10 days	Subtypes of adenomas: tubular adenomas, tubulovillous adenomas, sessile serrated adenomas and adenocarcinomas

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026