Periodontitis, Adult
Conditions
Brief summary
The buccal cavity is colonized by numerous microorganisms whose the number and composition could be modified with medical background (diseases and drugs) and the level of oral hygiene of the patients. Among all microorganisms identified in the periodontium, few of them are implicated in the etiopathogenesis of periodontal pathologies. To date, four major bacteria are identified for their ability to degrade periodontal tissues. Although the periodontitis is established to be the consequence of bacterial virulence and immune dysfunction, these factors fail to explain the refractory periodontitis of some patients to etiologic treatment . Others microorganisms such as protozoans could have an impact on this disease.
Interventions
OTHERnon applicable
non applicable
Sponsors
Centre Hospitalier Universitaire de Nice
University Hospital, Toulouse
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adults \> 18 years-old * consulting in periodontal department of CHRU * Patients with moderate to severe periodontitis * At least 2 periodontal sites with PPD ≥ 5mm and one healthy site * No scaling root planing in the last 6 months * Patients insured under the Franch social security system
Exclusion criteria
* Pregnants patients * Patients with antibiotic therapy and/ or all medecines which could modify the buccal microbiota in the last 6 months * Tooth with endodontics periapical lesion * Patients having a scaling root planing in the last 6 months * Patients with guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| presence of protozoans | 6 months after the last inclusion: DNA samples were frozen and identified later. | identification of protozoans by molecular technique (PCR) - |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Periodontal pocket depth (PPD in mm) | One day: measure realised during examination of the patient for periodontal treatment. | Measure of PPD thanks to periodontal probe |
| Clinical attachment Loss (CAL in mm) | One day: measure realied during clincal examination of patient. | Measure of CAL with periodontal probe |
| Plaque and gingival index | One day: measure of index during the clinical examination of patient. | Measure of plaque and gingival index (Loe and Silness, Silness and Loe) |
| Mobility of tooth | One day: measure of tooth mobility during the clinical examination of patient. | Measure of tooth mobility: Yes or not |
| Bleeding On Probing (BOP) | One day: measure of BOP during the clinical examination of patient. | Measure of BOP : Yes or not |
Countries
France
Contacts
Primary ContactEl Mehdi SIAGHY
Outcome results
None listed