Anesthesia, General
Conditions
Keywords
Preoxygenation, Oxygen Concentration
Brief summary
The use of 100% oxygen during the induction of general anesthesia is always preferable to have enough time to secure the airway by endotracheal intubation, because preoxygenation with a low oxygen concentration may reduce the safe time for apnea. However, using a low oxygen concentration during preoxygenation might prevent the formation of atelectasis. There is still no clear conclusion about the best oxygen concentration for preoxygenation. Our study is designed to evaluate the safety of preoxygenation with 80%, 60%, 40%, 30% and 21% oxygen by the safe time for apnea during the induction of general anesthesia.
Detailed description
We decide to add 3 groups (80%, 60%, and 40% oxygen) in our study to fully evaluate the safety of preoxygenation with different oxygen concentration. Zijia Li 2018.3.2
Interventions
DRUG100% Oxygen
Conventional preoxygenation with 100% oxygen
DRUG30% Oxygen
preoxygenation with 30% oxygen
DRUG21% Oxygen
preoxygenation with 21% oxygen
DRUG40% Oxygen
preoxygenation with 40% oxygen
DRUG60% Oxygen
preoxygenation with 60% oxygen
DRUG80% Oxygen
preoxygenation with 80% oxygen
Sponsors
Sixth Affiliated Hospital, Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Nonsmoking patients aged 18 years to 60 years * Undergoing general anesthesia for elective surgery * Pulse oxygen saturation ≥95% when breathing air quietly in bed * American Society of Anesthesiologists(ASA) physical status class I-II * Informed consent can be obtained
Exclusion criteria
* A suspected difficult airway * Be allergic to midazolam, propofol , fentanyl or Cisatracurium * Severe disease of respiratory system or cardiovascular system,or obstruction of the digestive tract * Oxygen reserve is suspected low,or patient who does not tolerate hypoxemia well * A history of mental disorder or patient who can not collaborate well * Body mass index more than 30 kg/㎡
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Safe time for apnea | 10 min | Time when peripheral oxygen saturation (SpO2) is ≥ 90% after preoxygenation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time needed for endotracheal intubation | 1 min | Time from when the laryngoscope blade first passes the lips to when the cuff of tracheal tube is inflated. |
Countries
China
Outcome results
None listed