Functional Disturbance, Physical Activity
Conditions
Keywords
knee osteoarthritis, hyaluronic acid, dextrose, therapeutic effects
Brief summary
Using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ultrasound guided hyaluronic acid injection and hyaluronic acid combined dextrose injection to patients with knee osteoarthritis.
Detailed description
A total of 106 patients will be collected. The participants will be randomized into two groups, including hyaluronic acid group and hyaluronic acid combined dextrose group. The hyaluronic acid group will receive 3 times of hyaluronic acid injection per week in three weeks; the hyaluronic acid combined dextrose group will receive 3 times of hyaluronic acid combined dextrose injection per week in three weeks. The pain, physical activity, and functional performance will be evaluated. All the evaluations will be re-evaluated at one week after injection, one month after injection, three months after injection, and six month after injection. Subjects and the evaluator will be both blinded to the group's classification during the whole course of study.
Interventions
DRUGdextrose
compare the therapeutic effects of hyaluronic acid combined dextrose injections with hyaluronic acid injections only to patients with knee osteoarthritis
DEVICEhyaluronic acid
compare the therapeutic effects of hyaluronic acid combined dextrose injections with hyaluronic acid injections only to patients with knee osteoarthritis
Sponsors
Taipei Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* knee osteoarthritis with Kellgren/Lawrence grade II or III
Exclusion criteria
* who have neurological deficit, such as stroke who have implant in knee
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| physical activity-on level walking time | changes from baseline to at one week after injection, one month after injection, three months after injection, and six month after injection | 10 meter walking |
| physical activity-stair climbing time | changes from baseline to at one week after injection, one month after injection, three months after injection, and six month after injection | stairs climbing |
| physical activity-chair rising time | changes from baseline to at one week after injection, one month after injection, three months after injection, and six month after injection | chair rising |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| functional performance | changes from baseline to at one week after injection, one month after injection, three months after injection, and six month after injection | Western Ontario and McMaster Universities Osteoarthritis index |
| quality of life | changes from baseline to at one week after injection, one month after injection, three months after injection, and six month after injection | Knee Injury and Osteoarthritis Outcome Score |
Countries
Taiwan
Contacts
Primary ContactRu-Lan Hsieh
Backup ContactRu-Lan Hsieh
Outcome results
None listed