Conditioned Pain Modulation Using Painful Cutaneous Electrical Stimulation or Simply Habituation?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03237650

Enrollment

Registered

2017-08-02

Start date

2016-04-30

Completion date

2016-09-30

Last updated

2017-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Habituation

Keywords

Painful cutaneous electrical stimulation, Conditioned Pain Modulation

Brief summary

Painful cutaneous electrical stimulation (PCES) and corresponding evoked potentials led to a significant pain relief and decrease of evoked potentials and has been used to analyze conditioned pain modulation (CPM). However, it is unknown whether the pain relief results from habituation to the repeated painful electric stimulation. We compared the effects of CPM and habituation on PCES-induced pain and PCES-evoked potentials and analyzed whether increased attention by a random change of electric intensities amplifies the habituation effects.

Interventions

None listed

Study design

Observational model

CASE_CROSSOVER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers

Exclusion criteria

* any kind of disease

Design outcomes

Primary

Measure	Time frame	Description
pain relief	during the measurement	pain intensity of painful cutaneous electrical stimulation on a numeric rating scale (NRS 0-100)
N1P1-amplitude	during the measurement	Amplitudes of painful cutaneous electrical stimulation evoked potentials in µV

Secondary

Measure	Time frame	Description
N1-latency	during the measurement	Latency of the peak N1 of painful cutaneous electrical stimulation evoked potentials in msec
P0N1-amplitude	during the measurement	Amplitudes of painful cutaneous electrical stimulation evoked potentials in µV

Outcome results