Obesity, Overweight, Physical Activity
Conditions
Keywords
Obesity, Microcirculation, Endothelial function, Laser speckle imaging, Capillary density
Brief summary
The study investigates the effects of high intensity interval training (HIIT) versus continuous training (CT), combined or not with fasting, on capillary density, microvascular function, cardiometabolic risk markers, functional capacity, and quality of life, in overweight or obese sedentary women with cardiometabolic risk factors. The use of HIIT could promote greater improvements in these parameters than CT. Furthermore, the positive effects of exercise may increase when it is performed in the fasting state, compared to exercise performed in the fed state.
Detailed description
Physical inactivity and increased caloric intake play important roles in the pathophysiology of obesity. Increases of physical activity and modifications of eating behaviors are first-line interventions which, however, are not easily implemented, and lack of time to exercise and difficulties in coping with different diets are common reasons for failure. High-intensity interval training (HIIT) is a faster alternative to moderate-intensity continuous training (CT). Conversely, intermittent fasting is also an alternative to more complex diets, as it restricts caloric intake to a specified period of time without major diet composition changes. The combination of HIIT and fasting may therefore provide incremental benefits. Sedentary women aged ≥ 30 years and ≤50 years, with body mass index ≥25 kg/m2 and cardiometabolic risk factors, will be randomized to HIIT performed in the fasting state, HIIT performed in the fed state, CT in the fasting state or CT in the fed state. Cardiometabolic parameters, anthropometric indices, cardiorespiratory fitness, quality of life and microvascular function (cutaneous capillary density and microvascular reactivity evaluated by laser speckle contrast imaging) will be evaluated before the initiation of the interventions and 4 weeks thereafter.
Interventions
BEHAVIORALHigh-intensity interval exercise training in the fed state
High-intensity interval exercise training in the fed state
BEHAVIORALContinous exercise training in the fed state
Continous exercise training in the fed state
BEHAVIORALHigh-intensity interval exercise training in the fasting state
High-intensity interval exercise training in the fasting state
BEHAVIORALContinous exercise training in the fasting state
Continous exercise training in the fasting state
Sponsors
National Institute of Cardiology, Laranjeiras, Brazil
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Female gender * Age≥ 30 years and ≤50 years * Premenopausal status * Body mass index \>25 kg/m2 * At least one of the following: waist circumference ≥80 cm (women); triglycerides ≥150 mg/dl or treatment for this lipid abnormality; High density-lipoprotein cholesterol \<50 mg/dl (women), or treatment for this abnormality; fasting plasma glucose ≥100 mg/dl
Exclusion criteria
* Any cardiovascular disease, including systemic hypertension * Diabetes mellitus * Chronic pulmonary disease * Any systemic disease or condition that might reduce the adherence or tolerance to exercise or fasting * Orthopedic or neurologic conditions that might impair exercise training * Pregnancy or breastfeeding * Abnormalities elicited at exercise treadmill testing that preclude the initiation of exercise training * Current engagement in any exercise training protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Capillary density | 6 months | Number of spontaneously perfused skin capillaries per mm2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microvascular reactivity assessed by laser speckle contrast imaging | 6 months | Skin microvascular flow in arbitrary perfusion units |
Countries
Brazil
Outcome results
None listed