DS vs SIPS-Bariatric Surgery Comparasion

The Single Anastomosis, 300 cm Loop, Duodenal Switch (SIPS) Results in Less Nutritional Deficiencies Than the Standard Duodenal Switch (DS) Operation: A Multicenter, Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03236142

Enrollment

110

Registered

2017-08-01

Start date

2017-01-31

Completion date

2025-01-31

Last updated

2018-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bariatric Surgery Candidate

Keywords

bariatric, duodenal switch, DS, weight loss surgery, SIPS, Single Anastomosis

Brief summary

The aim of this study is to answer the question of whether the single anastomosis, 300 cm loop, duodenal switch (SIPS) is an equally effective, safe, simpler operation with less nutritional and surgical risks than the standard duodenal switch (DS) operation. Please note, this study does not provide a stipend or coverage for surgery.

Interventions

PROCEDURESIPS Operation

The SIPS modification of the DS operation entails one less division of the small intestine and one less anastomosis, thereby reducing the time of the procedure.

PROCEDUREStandard Duodenal Switch Operation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Body mass index (BMI) of 40 to 65 * Agree to not use weight loss medications for the length of the study * Compliance with standards of surgical program

Exclusion criteria

* Patients with a history of previous bariatric surgery except for patients who have had a previous gastric sleeve * Previous complex abdominal surgery * Poorly controlled medical or psychiatric disease

Design outcomes

Primary

Measure	Time frame	Description
Vitamin A Deficiency	36 months post surgery	Proportion of patients with a vitamin A deficiency

Secondary

Measure	Time frame	Description
Vitamin D, zinc, copper, and albumin	36 months post surgery	Proportion of patients with vitamin D, zinc, copper, and albumin deficiency
Frequency of stools	36 months post surgery	Amount of stools per day
Length of Operation	Date of operation	Length of surgical procedure in time
Percentage of excess weight lost	36 months post surgery	Weight in excess of a body mass index (BMI) of 25.0 lost
Body Mass Index (BMI)	36 months post surgery	Body mass index (weight in kilograms divided by height in meters squared

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026