nCPAP, BiPAP, Respiratory Distress Syndrome
Conditions
Brief summary
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -bi-level positive airway pressure(BiPAP) or nasal continuous positive airway pressure (nCPAP) -as a primary mode of ventilation in preterm twins infants with respiratory distress syndrome
Detailed description
Invasive ventilation is related to development of adverse pulmonary and nonpulmonary outcomes in ventilated infants. Various modes of noninvasive respiratory support are being increasingly used to minimize the incidence of bronchopulmonary dysplasia (BPD). The aim of this trial to compare the effects of bi-level positive airway pressure(BiPAP) and nasal continuous positive airway pressure (NCPAP) in preterm twins infants as the primary mode.
Interventions
DEVICEBiPAP
BiPAP is used as a primary mode of ventilation in one of the preterm infants with respiratory distress syndrome
DEVICEnCPAP
nCPAP is used as a primary mode of ventilation in another of the preterm infants with respiratory distress syndrome
Sponsors
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
BiPAP and nCPAP are used as primary mode of ventilation in preterm twins infants with RDS
Eligibility
Sex/Gender
ALL
Age
5 Minutes to 6 Hours
Healthy volunteers
No
Inclusion criteria
* 1\. Gestational age (GA) is from 26 to 37 weeks; * 2\. Diagnosis of respiratory distress syndrome. The diagnosis of respiratory distress syndrome will be based on clinical manifestations (tachypnea, nasal flaring and or grunting) and chest X-ray findings; * 3\. Respiratory distress syndrome Silverman score \>5; * 4\. Informed parental consent has been obtained.
Exclusion criteria
* 1\. Severe respiratory distress syndrome requiring early intubation according to the American Academy of Pediatrics guidelines for neonatal resuscitation; * 2\. Major congenital malformations or complex congenital heart disease; * 3\. Group B hemolytic streptococcus pneumonia, septicemia, pneumothorax, pulmonary hemorrhage; * 4\. Cardiopulmonary arrest needing prolonged resuscitation; * 5\. transferred out of the neonatal intensive care unit without treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| intubation rate | within 7 days | the baby was intubated |
Countries
China
Contacts
Primary ContactMa Juan, MD
Backup ContactMa Juan, MD
Outcome results
None listed