Microbial Colonization, Microbial Substitution, Microbial Superinvasion, Newborn Morbidity
Conditions
Keywords
microbiome, preterm, newborn, gut microbiome, allergic predisposition
Brief summary
This is single center study. The investigators will try to know that relationships between intestinal microbiome and mortality in preterm infants and what relationships is between intestinal microbiome in preterm infants and morbidity, mortality.
Detailed description
Microbiome is the collection of all the microorganisms living in association with the human body which are consist of eukaryotes, archaea, bacteria and viruses. Microbiome in an average human body number are ten times more than human cells and have about 1000 more genes than are present in the human genome. There are symbiotic relationships between human and microbiome. If investigators are able to know about relationships between newborn and intestinal microbiome, mortality and morbidity in preterm infants may be improved. The investigators will collect the first and weekly stool of participants and analyze DNA of microbiome thorough Metagenomic anlysis. The results between 3 groups(preterm, late preterm and full-term infants) will be compared. The investigators expect that a mean distribution of intestinal microbiome in newborns(preterm, late preterm and full-term) is defined and that relationships between mortality, morbidity and intestinal microbiome.
Interventions
None listed
Sponsors
Wonju Severance Christian Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 1 Days
Healthy volunteers
No
Inclusion criteria
* preterm infants who were born at gestational age of less than 36 weeks from approval date to Feb 28th 2019 * full-term infants who were born at gestational age of greater than 37 weeks from approval date to Feb 28th 2019
Exclusion criteria
* newborns with congenital anomaly * newborns with genetic syndrome * newborns without consent of parents
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intestinal microbiome | for 2 years | The distribution rate of intestinal microbiome of stool by K-mer based taxonomic assignment which is one of the analysis in result of metagenomics in each infants |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Full Enteral feeding in preterm infants | for 2 years | Days to accomplish a full-enteral feeding in each infants |
| Growth rate | for 2 years | Days to reach 2 kg of body weight in each infants |
| Mortality | for 2 years | Number of patients who died in neonatal intensive care unit. |
| Morbidity | for 2 years | Number of patients who had a complication of preterm infants(e.g. necrotizing enterocolitis, bronchopulmonary dysplasia) or were died in neonatal intensive care unit. |
| Allergic predisposition | for 2 years | Number of patients who were developed a allergic predisposition at 6 month of postnatal age. |
Countries
South Korea
Contacts
Primary ContactByoungkook Lee
Outcome results
None listed