Dexmedetomidine
Conditions
Brief summary
Neuroapoptosis is induced by the administration of anesthetic agents to the young brain. Recent studies showed that the a2-adrenoceptor agonist, dexmedetomidine plays a trophic role during development and is neuroprotective in several settings of neuronal injury in animals. We hypothesized that neuroprotective effect of dexmedetomidine would be associated with evidence of brain injury detected by elevation of plasma concentration of glial fibrillary acid protein in children undergoing general anesthesia.
Detailed description
GFAP measure
Interventions
DRUGDexmedetomidine Hydrochloride
dexmedetomidine 1mcg/kg loading and 0.5mcg/kg/hr continuous infusion during surgery
OTHERcontrol
0.9% normal saline continuous infusion
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Months to 3 Years
Healthy volunteers
No
Inclusion criteria
* children undergoing general anesthesia longer than 3 hours
Exclusion criteria
* past history of anesthesia * cardiopulmonary bypass * preexisting neurocognitive dysfunction * abnormalities of liver profile (aspartate transaminase \> 40 unit/L, alanine aminotransferase \> 40 unit/L)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glial fibrillary acid protein | change from baseline glial fibrillary acid protein at 3 hours after the anesthetic induction | plasma was collected at the given specific time |
Countries
South Korea
Outcome results
None listed