A Prognosis and Predicting Genetic Study of Lung Cancer

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03234179

Enrollment

500

Registered

2017-07-31

Start date

2017-08-01

Completion date

2037-08-01

Last updated

2017-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genetic Predisposition to Disease, Lung Cancer

Keywords

Non small cell lung cancer, Genetic study

Brief summary

Lung cancer is a leading cause of cancer mortality among adults worldwide. The incidence rates of lung cancer among never smoking females in some parts of East Asia are among the highest in the world. The adenocarcinoma of lung being the most frequently identified histological type is more weakly associated with smoking, and often occurs in females and never-smokers. Although family history of lung cancer has been associated with histological subtypes, the inherited susceptibility factors that affect specific histology are unknown. Genetic factors that determine individual predisposition to lung cancer have been identified via genome-wide association studies. These known common loci, however, explain only a small fraction of the familial risk of lung cancer. The hypothesis of this study is that there are genetic factors that confer inherited susceptibility among patients with primary non-small-cell lung cancer (NSCLC).

Detailed description

To delineate the genetic etiology underlying NSCLC, this study proposes to employ a family-based linkage analysis, together with rich data generated from NGS, to search for disease susceptibility locus for the patients with strong family history of primary NSCLC. By using family pedigrees, linkage analysis will be able to find co-segregation of alleles through multiple generations at a genetic susceptibility locus and a known genetic marker, and then the highly penetrate gene loci may be detected by our study. These gene loci will be a good genetic predictor of NSCLC which should be a great advantage in treatment, prevention and screening of NSCLC in the future.

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

1. The patient's family (within third-degree relatives) has at least one diagnosed of primary non-small cell lung cancer. 2. The patient was diagnosed of primary non-small cell lung cancer at the age \< 45 years old.

Exclusion criteria

1. Patients without the diagnosis of primary non-small cell lung cancer. 2. Patients who are combined with other malignancy and ongoing chemotherapy / radiation therapy. 3. Patients combined with coagulopathy.

Design outcomes

Primary

Measure	Time frame	Description
Genetic information of lung cancer patients	One week after the study subjects sign the permit of informed consents	Collect study subjects' blood sample and analysis with Genome-wide SNP genotyping

Contacts

Primary ContactTung-Ming Tsai, MD

eldorado0607@gmail.com+886972792011

Backup ContactJin-Shing Chen, PhD

chenjs@ntu.edu.tw+8869721451

Outcome results