Cardiovascular Surgical Procedure
Conditions
Keywords
Inhaled anesthesia, Total intravenous anesthesia
Brief summary
This study compares the difference in proinflammatory markers Interleukin 6 (IL-6), Tumor necrosis factor alpha (TNFα) and cortisol in patients undergoing cardiovascular surgery to asses if there is a benefit of using intravenous total anesthesia (TIVA) over inhaled anesthesia for this procedures.
Detailed description
IL-6, TNFα and cortisol will be measure at the beginning of the cardiovascular surgery and 20 minutes after the cardiovascular bypass ends to calculate the difference between them and compare if there is any statistical difference between the proinflammatory markers with the two anesthesia techniques.
Interventions
DRUGPropofol
Propofol anesthesia Dose: 4-6mg/kg/h
DRUGSevoflurane
Inhaled anesthesia with sevoflurane. Dose: 1-2.5 Minimum Alveolar Concentration(MAC)
Sponsors
Coordinación de Investigación en Salud, Mexico
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
Scheduled for cardiovascular surgery American Society of Anaesthesiologists (ASA) physical status classification II-IV BMI \< 25 HbA1c \< 7%
Exclusion criteria
Diabetic patients Known allergy to propofol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IL-6 | The difference between IL-6 at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass | IL-6 will be compared between the groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TNFα | The difference between TNFα at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass | TNFα will be compared between the groups |
| Cortisol | The difference between cortisol at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass | Cortisol will be compared between the groups |
Countries
Mexico
Outcome results
None listed