Metabolism Disorder, Overweight and Obesity
Conditions
Brief summary
The investigators will retrospectively analyze and compare data of 2 groups of overweight and obese patients: subjects who followed a diet based on Resting Energy Expenditure (REE) measured by indirect calorimetry and subjects who followed a diet based on REE estimated by the Harris-Benedict equation. Propensity score adjustment will be used to adjust for known differences between the 2 groups
Interventions
DIAGNOSTIC_TESTIndirect calorimetry
Indirect calorimetry will be performed by using an open-circuit calorimeter (Sensor Medics, Italy). Indirect calorimetry is the reference method for energy expenditure determination. A canopy hood covered the patient's head and expired air is extracted by a pump to be analyzed by metabolic cart sensors; flow rate is directly measured with a digital turbine flowmeter. After an overnight fast, patients will asked to lay supine in complete physical rest, not sleeping or talking for approximately 20-25 minutes, at a room temperature ranged between 22 and 24°C. The mean REE for each participant considers the last 15-20 minutes of measurements corresponding to steady state. Software of calorimeter will be set for minute-by-minute reading report of VO2 (Oxygen flow) and VCO2 (Carbon dioxide flow) measurement. Parameters obtained by Indirect Calorimetry will be the Resting Energy Expenditure and the Respiratory Quotient (RQ)
Sponsors
Ospedale San Donato
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 86 Years
Healthy volunteers
No
Inclusion criteria
* BMI \>25 * Age ranging from 20 to 86 years
Exclusion criteria
* BMI\<25 * Age \<20 * Age \>86
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight in Indirect Calorimetry group and in NO Indirect Calorimetry group | 18 months | To compare body weight variation (kg) in two groups of overweight or obese patients: subjects who followed a diet formulated on REE measured by IC (IC group) and subjects who followed a diet based on REE predicted by the Harris-Benedict formula (NO-IC group) |
| BMI in Indirect Calorimetry group and in NO Indirect Calorimetry | 18 months | To compare BMI variation (kg/m\^2) in two groups of overweight or obese patients: subjects who followed a diet formulated on REE measured by IC (IC group) and subjects who followed a diet based on REE predicted by the Harris-Benedict formula (NO-IC group) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Weight in male/female in Indirect Calorimetry group and in NO indirect Calorimetry group | 18 months | To identify gender differences in weight variation (kg) between IC and NO-IC groups |
| BMI in male/female in Indirect Calorimetry group and in NO indirect | 18 months | To identify gender differences in BMI variation (kg/m\^2) between IC and NO-IC groups |
Other
| Measure | Time frame | Description |
|---|---|---|
| Weight in subjects with RQ<0.9 and subjects with RQ>0.9 | 18 months | to compare body weight variation in 2 subpopulation of the IC group: subjects with an RQ ≤ 0.9 and subjects with RQ \> 0.9. |
| BMI in subjects with RQ<0.9 and subjects with RQ>0.9 | 18 months | BMI variation in 2 subpopulation of the IC group: subjects with an RQ ≤ 0.9 and subjects with RQ \> 0.9. |
| Tryglycerides in Indirect Calorimetry group and in NO Indirect Calorimetry Group | 18 months | to identify differences in tryglycerides (mg/dl) variation between IC and NO-IC groups |
| Hemoglobin in Indirect Calorimetry group and in NO Indirect Calorimetry Group | 18 months | to identify differences in glycated hemoglobin (%) variation between IC and NO-IC groups |
| Uric acid in Indirect Calorimetry group and in NO Indirect Calorimetry Group | 18 months | to identify differences in uric acid (mg/dl) variation between IC and NO-IC groups |
| Glucose in Indirect Calorimetry group and in NO Indirect Calorimetry Group | 18 months | to identify differences in glucose (mg/dl) variation between IC and NO-IC groups |
| Total cholesterol (mg/dl) in Indirect Calorimetry group and in NO Indirect Calorimetry Group | 18 months | to identify differences in cholesterol variation between IC and NO-IC groups |
| Weight in adequate to predicted REE and in NOT adequate to predicted REE subpopulations | 18 months | to compare body weight variation (kg) in two sub-populations of the IC-group: subjects with adequate to predicted REE and subjects with not adequate to predicted REE |
| BMI in adequate to predicted REE and in NOT adequate to predicted REE subpopulations | 18 months | to compare BMI variation in two sub-populations of the IC-group: subjects with adequate to predicted REE and subjects with not adequate to predicted REE |
Countries
Italy
Outcome results
None listed