Posner Schlossman Syndrome
Conditions
Keywords
Posner Schlossman Syndrome, cytokine expression, cytomegalovirus
Brief summary
Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a condition characterized by recurrent, acute attacks of mild, nongranulomatous, anterior uveitis accompanied by markedly elevated intraocular pressure. Most of patients are the 20 to 50-year-old young adults, with unilateral eye involvement. PSS was originally deemed benign, but is now recognized as a relatively rare cause of chronic secondary glaucoma,especially in patients with recurrent episodes. This relatively rare disease is likely the result of the infections of a variety of organisms, and the bulk of literature supports the cytomegalovirus (CMV) as the leading cause. This study is an observational study that does not interfere with the normal clinical diagnosis and treatment process. The investigators in this study focus on observing the clinical symptoms and outcome of PSS, analyzing the factors that affect the prognosis of PSS, studying the association of its pathogenesis with the psychological status and the behavioral types of PSS patients; exploring the relationship between infection (CMV, HSV, Hp) and PSS; and studying the changes of local and systemic cytokine expression and its significance in patients with PSS.
Interventions
None listed
Sponsors
Peking University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Volunteer to take part in this study and sign informed consent by oneself or the patient's legal representative * Clinical diagnosis of Posner-Schlossman Syndrome, age-related cataract, or primary open-angle glaucoma * Live in Beijing, China or being able to visit the Peking University Third Hospital every year after the beginning of the study or whenever the disease relapses
Exclusion criteria
* Fit any
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| demographic characteristics | up to 10 years | age, sex, education level, systemic disease， mental state |
| visual acuity | up to 10 years | uncorrected visual acuity and best corrected visual acuity |
| intraocular pressure | up to 10 years | Goldmann |
| slit-lamp examination | up to 10 years | anterior segment |
| fundus photograph | up to 10 years | analysis the morphology of optic nerve head |
| OCT | up to 10 years | zess |
| visual field | up to 10 years | Humphrey visual field |
| blood serum | up to 10 years | 8ml |
| aqueous humor | up to 10 years | 0.2ml |
| tissue | in the operation | iris and& or trabecular meshwork tissue abandoned in the anti-glaucoma operation |
Countries
China
Contacts
Primary ContactShushan Li, MD
Outcome results
None listed