Chronic Pain
Conditions
Keywords
Magnetoencephalography, Whole-cortex MEG System (with optional EEG)
Brief summary
The primary purpose of this study is to determine the effectiveness of the Magnetoencephalography (MEG) instrument to record electrical activity from parts of the body other than the brain. This study will examine if electrical activity from parts of the body, other than the brain, can be imaged by the MEG instrument. Finding will contribute to studies of pain, since abnormal electrical activity in skeletal muscle is the basis of pain, which can be severe, yet there is no non-invasive way to image this abnormal activity. This is particularly relevant to deep muscle pain and back pain.
Interventions
DIAGNOSTIC_TESTWhole-cortex MEG System (with optional EEG)
Whole-Cortex MEG System non- invasively measures the magnetoencephalographic (MEG) signals (and, optionally, electroencephalographic EEG signals) produced by electrically active tissue of the brain. These signals are recorded by a computerized data acquisition system, displayed, and may then be interpreted by trained physicians to help localize these active areas. The location may then be correlated with anatomical information of the brain. MEG is routinely used to identify the locations of visual, auditory, somatosensory, and motor cortex in the brain.
Sponsors
NYU Langone Health
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults who are willing and able to provide informed consent.
Exclusion criteria
* Subjects with characteristics incompatible with MEG recordings as listed on the MEG Safety checklist (Appendix A), * Involuntary, uncontrolled tremor, * chronic pain. * pregnant women (based on self-report).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination of optimal position to obtain safe and effective imaging of structures other than the brain. | 2 Weeks | * Hand position 1 relaxed * Hand position 1 muscles active * Hand position 2 relaxed * Hand position 2 muscles active * Neck and Jaw, relaxed * Neck and Jaw, tensed * Upper torso relaxed * Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) |
| Evoked activity to obtain safe and effective imaging of structures other than the brain | 2 Weeks | * Hand position 1 relaxed * Hand position 1 muscles active * Hand position 2 relaxed * Hand position 2 muscles active * Neck and Jaw, relaxed * Neck and Jaw, tensed * Upper torso relaxed * Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dominant frequency of non-brain electrical activity in healthy adults. | 2 Weeks | * Hand position 1 relaxed * Hand position 1 muscles active * Hand position 2 relaxed * Hand position 2 muscles active * Neck and Jaw, relaxed * Neck and Jaw, tensed * Upper torso relaxed * Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) |
| Location of non-brain of activity in healthy adults. | 2 Weeks | * Hand position 1 relaxed * Hand position 1 muscles active * Hand position 2 relaxed * Hand position 2 muscles active * Neck and Jaw, relaxed * Neck and Jaw, tensed * Upper torso relaxed * Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) * Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) |
Countries
United States
Outcome results
None listed