Postoperative Pain
Conditions
Brief summary
The purpose of this study was to evaluate the efficacy of dexamethasone when added to epidural bupivacaine on the duration of postoperative analgesia in patients underwent total knee replacement surgery.
Detailed description
Fifty patients underwent total knee replacement were included in the study. The patients (11 male and 39 female) were classified into two equal groups:- The patients received 15 mL plain bupivacaine + 2 mL (BS), or 8 mg dexamethasone (BD). The total volume injected in both groups was 17 ml. Postoperative records: 1. Pain score (NRS) at base line, then every 4 hrs for 24 hrs. 2. Frequency of rescue analgesia. 3. Postoperative side effects like nausea, vomiting, and over sedation.
Interventions
DRUGDexamethasone
dexamethasone + plain Bupivacaine injected epidurally.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients scheduled for total knee replacement surgery. 2. ASA Physical status I,II,III.
Exclusion criteria
1. Patients' refusal. 2. Uncooperative patients / Not able to understand pain assessment test. 3. Patients with history of allergy to the used drugs. 4. Significant liver disease. 5. Pregnancy. 6. Any contraindication for epidural anesthesia 7. Failed technique.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| duration of postoperative analgesia (NRS) | 24 hrs postoperative | first patient request for analgesia or NRS 4 or more |
Outcome results
None listed