Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression Disorder

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03230682

Enrollment

Registered

2017-07-26

Start date

2017-07-25

Completion date

2018-07-11

Last updated

2017-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Keywords

early improvement, antidepressants, major depression diorder, resting-state fMRI

Brief summary

Early improvemrnt, decreased 20% in the 17 items of Hamilton Depression Rating Scale (HAMD-17) at the second week of the treatment of major depression disorder (MDD), can arguably predict the remission at the 12th week. Our observation study including 80 MDD patients will access resting-state function MRI to finding factors which infuencing early improvemrnt, respone and remission of antidepressants.

Interventions

DRUGantidepressant

regular one-drups treatment of selective serotonin reuptake inhibitor(SSRIs)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to 55 Years

Healthy volunteers

Inclusion criteria

* right-handed; HAMD-17 more than 17; diagnosed with MDD by the Structured Clinical Interview for DSM-IV

Exclusion criteria

* patients diagnosed with other condition in DSM-IV Axis I; pregnency; Thyroid disease; Heart Disease

Design outcomes

Primary

Measure	Time frame	Description
Early improvement	the second week of treatment	obtain 20% decrease of HAMD-17

Secondary

Measure	Time frame	Description
Response	the 12th week of treatment	obtain 50% decrease of HAMD-17

Countries

China

Contacts

Primary ContactShi Shenxun, PhD

shishenxun@163.com13816203171

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026