Effect of Bacterial Translocation
Conditions
Brief summary
The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.
Interventions
DIAGNOSTIC_TESTPCR for bacterial translocation
samples taken from the blood and ascites of patients to search for bacterial DNA
Sponsors
Alexandria University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Inclusion criteria
• patients with liver failure undergoing liver transplantation
Exclusion criteria
* Age less than 18 years; * Active overt infection; * Patients on oral or systemic anticoagulation or with known coagulopathic disorders apart from those caused by liver failure (eg.: Protein C or S deficiency, congenital platelet disorders and congenital coagulation disorders…etc); * Patients undergoing re-transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| antifactor X activity | at the beginning of surgery |
| change in the mean arterial blood pressure | at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase |
| change in the heart rate | at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase |
| change in the cardiac output | at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase |
Countries
Egypt
Outcome results
None listed