Boston Birth Cohort Study

Conditions

Birth Outcome, Adverse, Child Health, Maternal Health, Pregnancy Complications

Keywords

Boston Birth Cohort, Early life origins of pediatric and adult disease, Gene environment interaction, Health across life course and generations

Brief summary

Early life exposures may lead to adverse effects on health in later life. The Boston birth Cohort study is designed to study a broad array of early life factors and their effects on maternal and child health outcomes across the life course.

Detailed description

Any woman admitted to the Labor and Delivery floor at the Boston Medical Center (BMC) who delivers a singleton live infant and meets our case (gestational age \<37 weeks or birthweight \<2,500 grams) or control (full term birth with birthweight \>2,500 grams) criteria will be eligible. Postnatal follow-up of enrolled mother-child pair is conducted from birth to age 21 years. The Boston Birth Cohort has high-quality biospecimen collection, and comprehensive epidemiological, clinical, and environmental exposure data via standardized questionnaire interview, measurements, and review of the electronic medical records.

Anat Yaskolka Meir, Guoying Wang, Xiumei Hong, Frank B. Hu, Xiaobin Wang et al. (6 authors)

BMC Medicine2024-09-111 citations

10.1186/s12916-024-03568-9

Joint Associations of Pregnancy Complications and Postpartum Maternal Renal Biomarkers With Severe Cardiovascular Morbidities: A US Racially and Ethnically Diverse Prospective Birth Cohort Study

Xiumei Hong, Avi Z. Rosenberg, Jurgen Heymann, Teruhiko Yoshida, Sushrut S. Waikar et al. (13 authors)

Journal of the American Heart Association2023-11-101 citations

10.1161/jaha.122.029311

Trimethylamine N-Oxide and Its Precursors Are Associated with Gestational Diabetes Mellitus and Pre-Eclampsia in the Boston Birth Cohort.

McArthur KL, Zhang M, Hong X, Wang G, Buckley JP, Wang X, Mueller NT.

2022-06-2115 citations

10.1093/cdn/nzac108

In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals.

Huang W, Igusa T, Wang G, Buckley JP, Hong X, Bind E, Steffens A, Mukherjee J, Haltmeier D, Ji Y, Xu R, Hou W, Tina Fan Z, Wang X.

2022-05-1915 citations

10.1038/s41366-022-01127-x

Birth outcomes across the spectrum of maternal age: dissecting aging effect versus confounding by social and medical determinants.

Olapeju B, Hong X, Wang G, Summers A, Burd I, Cheng TL, Wang X.

2021-09-015 citations

10.1186/s12884-021-04077-w

Maternal Hypertensive Disorders in Pregnancy and Postpartum Plasma B Vitamin and Homocysteine Profiles in a High-Risk Multiethnic U.S., Population

Bolanle Olapeju, Saifuddin Ahmed, Xiumei Hong, Guoying Wang, Amber Summers et al. (8 authors)

Journal of Women s Health2020-11-3011 citations

10.1089/jwh.2020.8420

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

0 Years to 50 Years

Healthy volunteers

No

Inclusion criteria

* Mothers who deliver singleton live births at Boston Medical Center are eligible for the study.

Exclusion criteria

* pregnancies that are a result of in vitro fertilization or that involve multiple gestations, fetal chromosomal abnormalities or major birth defects.

Design outcomes

Primary

Measure	Time frame	Description
Participants with Pregnancy complications - including hypertensive disorders and gestational diabetes	At birth	hypertensive disorders during pregnancy, gestational diabetes
Birth outcomes - number of participants with preterm births	At birth	Birth outcomes are examined - preterm birth.
Birth outcomes - birth weight in grams (g)	At birth	Birth outcomes are examined - birth weight (g)
Child health outcomes - number of participants overweight or obese	From birth to 21 years	overweight or obesity
Maternal health outcomes - number of participants with maternal diabetes	After delivery to 21 years	maternal diabetes
child health outcome - systolic and diastolic blood pressure	from birth to 21 years	blood pressure (mmHg)
child health outcome - participants with neuro-developmental disorders including autism and ADHD	from birth to 21 years	neuro-developmental disorders including autism and ADHD
child health outcome - number of participants with asthma	from birth to 21 years	asthma

Countries

United States

Contacts

CONTACTXiaobin Wang, MD, ScD

xwang82@jhu.edu410-9555824

PRINCIPAL_INVESTIGATORXiaobin Wang, MD, ScD

Johns Hopkins Bloomberg School of Public Health

Outcome results