Headache, Migraine
Conditions
Keywords
Levcromakalim
Brief summary
To investigate the role of KATP channels on the cerebral hemodynamic in migraine patients.
Interventions
DRUGLevcromakalim
To investigate the role of Levcromakalim on cerebral hemodynamic in migraine patients
DRUGSaline
To investigate the role of levcromakalim compared with saline cerebral hemodynamic in migraine patients.
Sponsors
Danish Headache Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Migraine patients of both sexes. * 18-60 years. * 50-90 kg. * Women of childbearing potential must use adequate contraception.
Exclusion criteria
* Headache less than 48 hours before the tests start * Daily consumption of drugs of any kind other than oral contraceptives * Pregnant or nursing women. * Cardiovascular disease of any kind, including cerebrovascular diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral hemodynamic | Before (-10 min) and after infusion (+2 hours) of levcromakalim compared with before and after infusion of saline | Change on Media cerebri arterie. |
| Headache | Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline | Occurrence of headache. |
| Migraine attack | Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline | Occurrence |
Countries
Denmark
Outcome results
None listed