Rabies
Conditions
Keywords
rabies vaccination
Brief summary
To study the humoral and cell-mediated immune responses in HIV-infected adults who had previously received rabies booster vaccination more than a year before
Detailed description
Previous study has shown the higher immunogenicity response among HIV-infected adults who received a single visit 4-site intradermal rabies booster vaccination than those who received the conventional intramuscular regimen. The investigators follow the persistence of these effects. Also, the regulatory T cell levels were examined after the rabies booster vaccination .
Interventions
PROCEDUREBlood drawn after rabies booster vaccination
Blood would be drawn for testing of rabies neutralizing antibody titers, rabies specific T lymphocytes and regulatory T cells after receipt of rabies booster vaccination at least a year before.
Sponsors
Queen Saovabha Memorial Institute
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
The volunteers who participated in the previous clinical trials were invited to join this study. Of which, there were 2 groups, one received a single visit 4-site intradermal rabies booster vaccination. The another received a conventional intramuscular rabies booster vaccination on day 0 and 3.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Healthy HIV-infected adults * Previously received rabies booster vaccination by participation in the previous clinical trials of the investigators.
Exclusion criteria
* Have any active opportunistic infections * Received blood or blood product within 3 months * Received anti-malarial drugs * Received rabies vaccination in a previous year.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rabies Neutralizing Antibody Titers (RNab) | GMTs of RNab and proportion of volunteers who have had RNab above protective antibody levels (0.5 IU/ml) after receipt of rabies booster vaccination at least a year before were compared between 2 arms at one time point on the date of study recruitment. | Rabies Neutralizing Antibody Titers would be represented and compared by geometric mean titers (GMTs) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rabies specific T cell response | Numbers of spots, of which represent the rabies specific T cell response after receipt of rabies booster vaccination at least a year before were compared between 2 arms at one time point on the date of study recruitment. | Rabies specific T cell response is measured by Enzyme - linked Immunospot Assay (ELISPOT) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Rabies specific regulatory T cells | Numbers of Rabies specific regulatory T cells after receipt of rabies booster vaccination at least a year before were compared between 2 arms at one time point on the date of study recruitment. | Rabies specific regulatory T cells is measured by flow cytometry method |
Countries
Thailand
Contacts
Primary ContactSuda Sibunruang, MD
Backup ContactTerapong Tantawichien, MD
Outcome results
None listed