Parkinson's Disease
Conditions
Brief summary
Depression is common in Parkinson's disease (PD), but the effective treatment is not established yet. tDCS is a non-invasive brain stimulation to modulate brain function. The tDCS on the depression in general population were already conducted, but not in PD. This study is to know whether transcranial direct current stimulation (tDCS) is effective for the treatment of depression in PD. Participant will be asked to visit three consecutive days for the non-invasive stimulation.
Interventions
DEVICEtranscranial direct current stimulation (tDCS)
tDCS is one of non-invasive brain stimulation. Constant, low current is delivered to the specific brain areas to change brain plasticity.
Sponsors
Inje University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Intervention model description
Randomized, Parallel, Sham-controlled, single-blinded study
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* UK Parkinson's disease brain bank criteria * more than 19 years old * Able to provide consent for the protocol * Depression (based on DSM-IV criteria)
Exclusion criteria
* Dementia * Unpredictable symptom fluctuations * Contraindication to tDCS (i) irritations, cuts, lesions in the brain (ii) any preexisting unstable medical conditions, or conditions that may increase the risk of stimulation such as uncontrolled epilepsy (iii) history of severe cranial trauma with alteration of the cranial anatomy or metallic intracranial implants (iv) history of seizure * Subjects without the capacity to give informed consent * If participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as excessive fatigue, general frailty, or excessive apprehension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BDI score | (1) before the1st visit (within one month) (2) right after the 3rd tDCS (3) within one months after the 3rd tDCS | The changes of Beck depression inventory after tDCS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HDRS score | (1) before the 1st visit (within one month) (2) right after 3rd tDCS, within 24 hours (3) within one months after the 3rd tDCS | The changes of Hamilton Depression Rating Scale after tDCS |
| MADRS score | (1) before the 1st visit (within one month) (2) right after the 3rd tDCS, within 24 hours (3) within one months after 3rd tDCS | The changes of Mongomery-Asberg Depression Rating Scale after tDCS |
| resting state functional MRI | (1) before the 1st visit (within one month) (2) after the 3rd tDCS, within 24 hours (on the same day as the 3rd tDCS) | The changes of resting state functional MRI after tDCS |
Countries
South Korea
Contacts
Primary ContactSang Jin Kim, MD, PhD
Outcome results
None listed