Parkinson Disease
Conditions
Keywords
freezing of gait, Parkinson disease, GPi
Brief summary
This study aims to evaluate the effect of deep brain stimulation in the the globus pallidus (Gpi) on freezing of gait in patients with Parkinson's disease.
Interventions
None listed
Sponsors
Haiyan Zhou
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
(1) idiopathic PD, according to the MDS Parkinson's Disease Society Diagnostic Criteria17; (2) bilateral GPi-DBS implant according to a careful consideration of patients' symptom profiles (e.g., existence and severity of dyskinesia, dystonia, axial symptoms, or cognitive and mood problems); (3) onset of PD at or before 70 years of age; and (4) disease duration of more than 3 years at the time of surgery. Patients were excluded if they had unstable vital signs or medical and psychiatric comorbidities at the time of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changs in the score of Timed Up and Go Test | baseline, 12 month |
Secondary
| Measure | Time frame |
|---|---|
| Change of the score in GFQ | baseline, 12 month |
| Change of the score in FoG total time of TUG test | baseline, 12 month |
| Change of the score in Proportion of FoG of TUG test | baseline, 12 month |
| Change of the score in Longest FoG duration of TUG test | baseline, 12 month |
| Change of the score in FoG Episodes of TUG test | baseline, 12 month |
Other
| Measure | Time frame |
|---|---|
| Change of the scores in MDS-UPDRS | baseline, 12 month |
Countries
China
Outcome results
None listed