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Oral Fluency and the Response to Antidepressant Therapy in the Elderly With a Unipolar Depressive Episode

An Exploratory Study of the Use of Oral Fluency as a Predictive Tool for the Antidepressant Response of Elderly With Unipolar Depressive Disorder

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03227133
Acronym
PREDICTage
Enrollment
42
Registered
2017-07-24
Start date
2016-12-23
Completion date
2019-06-23
Last updated
2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unipolar Depression

Brief summary

The study focuses on the identification of clinical, physiological and morphological markers that could predict the response to antidepressant in elderly suffering from unipolar depressive disorder.

Interventions

OTHERNeuropsychological evaluations

Neuropsychological evaluations including oral fluency, performed specifically for the study

OTHERPsychiatric interview
OTHERCardiovascular risk assessment

Sponsors

Centre Hospitalier Universitaire de Besancon
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Depressive episode according to DSM-5 criteria * Unipolar depression * MADRS ≥ 20 * Antidepressive treatment (Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors)

Exclusion criteria

* Other comorbid mental disorders (bipolar disorder, schizophrenia, recent addiction \< 3 months except for tobacco) * Depression with psychotic features * Serious unstabilized somatic illness * Protected persons * Dementia suspected at the time of enrollment

Design outcomes

Primary

MeasureTime frameDescription
Ability of the verbal fluency test score to predict the response to antidepressive treatmentweek 10verbal fluency is assessed during the neuropsychological assessment

Countries

France

Contacts

Primary ContactJulie Monnin, PhD
jmonnin@chu-besancon.fr

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026