DNA Methylation and 1-C Metabolism Nutrient Intake

Dietary Intake of One-carbon Metabolism Nutrients and DNA Methylation in Peripheral Blood

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03227003

Enrollment

5983

Registered

2017-07-24

Start date

2014-01-01

Completion date

2015-12-31

Last updated

2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DNA Methylation

Brief summary

The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of DNA methylation using the HumanMethylation Infinium 450K Beadchip assay, or using LINE-1, Alu and Sat2 assays. The investigators studied the association between nutrients involved in one-carbon metabolism and DNA methylation in peripheral blood.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

27 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Selected into one of six case-control studies nested in the Melbourne Collaborative Cohort Study * Completed a 121-item Food Frequency Questionnaire * Had a blood DNA sample with a measure of methylation

Exclusion criteria

* Missing data in any of the outcome, exposure, or confounders (N=797 excluded)

Design outcomes

Primary

Measure	Time frame	Description
Blood DNA methylation	2014-2015	Methylation of DNA from peripheral blood, HumanMethylation 450 Beadchip assay

Secondary

Measure	Time frame	Description
Blood DNA methylation	2014-2015	Methylation of DNA from peripheral blood, LINE-1, Alu, Sat2

Outcome results