Lung Cancer, Lymphadenopathy
Conditions
Keywords
endobronchial ultrasound, high flow nasal oxygen
Brief summary
This study is a prospective randomised trial where a computer will randomly allocate patients to one of two possible methods of delivering oxygen during the procedure of bronchoscopy. This trial compares high flow nasal cannula (HFNC) with nasal prongs in delivering oxygen to patients undergoing endo-bronchial ultrasound guided trans- bronchial nodal aspiration (EBUS-TBNA) a specialised form of bronchoscopy procedure. HFNC uses humidified higher gas flow rates than conventional low flow systems such as nasal prongs which are limited by the respiratory rate and effort.
Interventions
DEVICEhigh flow nasal oxygen
humidified high flow nasal oxygen
Sponsors
University College Hospital Galway
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects with a peripheral arterial pulse oximetry ≥ 90% breathing room air * Age ≥ 18 years * Able to breathe spontaneously throughout the procedure
Exclusion criteria
* Respiratory or cardiac failure * Recent myocardial infarction \< 6 weeks ago * On long term oxygen therapy, those with tracheostomy and/ or non-invasive or invasive mechanical ventilation * Nasal and/ or nasopharyngeal disease * Inability to give informed consent * Dementia * Hepatic or end stage renal disease * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| drop in oxygen saturation during procedure | through procedure completion defined as withdrawing scope from patient's mouth, an average of 30 minutes | the difference in oxygen saturation levels between pre-treatment assessments and the lowest saturation level achieved during treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in venous CO2 | 1 hour after procedure | Change in venous CO2 1 hour after procedure compared to pre-procedure level |
| end tidal CO2 during procedure | through procedure completion defined as withdrawing scope from patient's mouth an average of 30 minutes | Measured with tip of scope at lower trachea |
| Patient experience measure on a visual analogue scale | up to 3 hours after procedure | — |
| endotracheal intubation during or post procedure | 24 hours | — |
Countries
Ireland
Outcome results
None listed