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Predictive Value of Aortic Stiffness on Recurrence of Atrial Fibrillation After Disconnection of Pulmonary Veins (VARIABLE).

Predictive Value of Aortic Stiffness on Recurrence of Atrial Fibrillation After Disconnection of Pulmonary Veins.

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03226639
Acronym
VARIABLE
Enrollment
100
Registered
2017-07-24
Start date
2016-11-30
Completion date
2018-05-31
Last updated
2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

First Ablation of Atrial Fibrillation

Keywords

Atrial Fibrillation, First Ablation

Brief summary

The ablation of atrial fibrillation (FA) by disconnection of pulmonary veins is a burgeoning intervention. It allows a long-term treatment of this arrhythmia with a success rate of about 80%. There are, nevertheless, some recidivism. Risk factors for recidivism are poorly codified and need further research. Indeed the identification of factors of poor prognosis could lead to not propose this procedure to the patients who present them and at least to inform them of an increased risk of failure. To date, aortic stiffness has not been studied in the context of assessing the risk factors for FA recurrence after ablation. On a physiopathological level, the aortic stiffness leads to increase left ventricle's post-load. Cardiac remodeling was observed with diastolic dysfunction and increased left atrial size. That may constitute a substrate for FA recurrence. In the literature, aortic stiffness can be measured in several ways: 1. Measurement of systolo-diastolic variation of the inner diameter of the aorta by scanner or transesophageal Echography (ETO). 2. Measuring of the Pulse Wave Velocity. 3. Measurement of aortic calcifications. The investigators propose to evaluate the impact of aortic stiffness on the recidivism of FA 6 months after ablation procedure performed in the Croix-Rousse cardiology's department.

Interventions

None listed

Sponsors

Hospices Civils de Lyon
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

: * 18 years old of both sexes, * Patient carrying a paroxysmal or persistent atrial fibrillation, benefiting from a first procedure of atrial fibrillation's ablation in the in the Croix-Rousse cardiology's department. * Patient who signed the consent to participate in the study.

Exclusion criteria

: * Patient carrying a permanent atrial fibrillation * Patient who're in atrial fibrillation during the ablation * Atrial fibrillation relapse's history after ablation * Pregnant and nursing women * Patients refusal.

Design outcomes

Primary

MeasureTime frameDescription
Atrial fibrillation recurrencesMonth 6Atrial fibrillation recurrences after 6 months of ablation by Holter ECG

Countries

France

Contacts

Primary ContactPierre LANTELME
pierre.lantelme@chu-lyon.fr+33 4 72 07 16 67
Backup ContactFatou LANGEVIN
fatou.langevin@chu-lyon.fr+33 4 72 07 28 65

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026