Community Epidemiology and Typology of Third-generation Cephalosporins Resistant Enterobacteriaceae in Reunion Island

Community Epidemiology and Typology of Third-generation Cephalosporins Resistant Enterobacteriaceae (Prevalence, Resistance Mechanisms and Risk Factors) in Reunion Island

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03226314

Acronym

AB-RUN

Enrollment

500

Registered

2017-07-21

Start date

2017-11-21

Completion date

2019-06-30

Last updated

2019-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial Resistance

Keywords

bacterial multi-resitance

Brief summary

In its report dated april 2014, World Health Organization confirms antibiotic resistance dissemination in all parts of the world, in hospitals and in community and worries about a possible comeback to a pre-antibiotic era during the 21st century. For the last 15 years, third-generation cephalosporins resistant enterobacteriaceae (3GCREB) prevalence is continuously increasing. Community 3GCREB prevalence has not been studied whereas several observations made in Reunion Island hospital suggest a diffusion in community. In this situation of world-wide and regional extension of bacterial resistance, the investigator offers to study bacterial resistance to antibiotic in Reunion Island community.

Detailed description

The investigator is focused on E. coli species exhibiting BLSE or metallo-betalactamases production that could be encountered du to the increasing level of migratory flow in Reunion Island. Fecal sample collection will be used for further investigations on bacterial typology.

Interventions

PROCEDUREstool sample

study will be proposed to all patients entering emergency ward or intensive care unit in Reunion Island university hospital. Upon consent, a stool sample will be taken (either directly on emitted stools or by rectal sampling) and analysed for enterobacteriaceae.

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Patients: * aged over 18 years old * admitted in emergency ward or intensive care of the university hospital of Reunion Island * who received the patient information notice and who gave their consent * who have a stool sample performed in the 48 hours following admission * who understand and can read French

Exclusion criteria

Patients: * transferred from a short-term, middle-term or long-term stay health facility * who have a stool sample performed more than 48 hours following admission.

Design outcomes

Primary

Measure	Time frame	Description
Digestive prevalence rate of 3GCREB	through study completion, an average of 1 day	estimate of digestive prevalence rate of 3GCREB in participating patients and extrapolation to Reunion Island community population.

Countries

Reunion

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026