Prospective Urban Rural Epidemiology Study

Conditions

Cancer, Cardiovascular Diseases, Communicable Disease, Environmental Exposure, Health Behavior, Injuries, Lung Diseases, Renal Disease, Risk Factor, Cardiovascular

Keywords

Non-communicable Diseases, Risk Factors

Brief summary

To examine the impact of health determinants at the individual (e.g. health related behaviors) and societal level (e.g. environmental factors, health related policy, quality of health systems) on health outcomes (e.g. death, non-communicable disease development) across a range of socioeconomic and health resource settings. Additional components of this study will examine genetic factors for non-communicable diseases. This will be examined both through a cross sectional component, and prospectively (cohort component).

Detailed description

1. To examine the relationship between societal influences and prevalence of risk factors and chronic noncommunicable diseases. Societal determinants are measured by an index of measures from each of the 4 domains of interest: built environment, food and nutrition policy, psychosocial/socioeconomic factors, and tobacco. 2. To examine the relationship between societal determinants and incidence of chronic noncommunicable disease events (e.g. cardiovascular disease, cancer) and on changes in rates of selected risk factors (e.g. smoking) 3. To examine the relationship between health related behaviors (e.g. diet, physical activity, smoking, alcohol) and health outcomes (e.g. death, non-communicable diseases) 4. The quality of health systems across a diverse range of health resource settings, and how this impacts health outcomes 5. Genetic factors for non-communicable diseases

Chen R, Liu Y, Yang S, Lin Z, Yu G, Wang W, Wei D, Li W, Wang H, Zhang M, Zhang P, Zhang Y, Zhou F, Ding R.

2025-10-21

10.1038/s41598-025-20683-6

Activity limitations, use of assistive devices, and mortality and clinical events in 25 high-income, middle-income, and low-income countries: an analysis of the PURE study.

Joundi RA, Hu B, Rangarajan S, Leong DP, Islam S, Smith EE, Mirrakhimov E, Seron P, Alhabib KF, Assembekov B, Chifamba J, Yusuf R, Khatib R, Felix C, Yusufali A, Mohammadifard N, Rosengren A, Oguz A, Iqbal R, Yeates K, Avezum A, Kruger I, Anjana R, Pvm L, Gupta R, Zatońska K, Barbarash O, Pelliza E, Rammohan K, Li M, Li X, Ismail R, Lopez-Jaramillo P, Evans M, O'Donnell M, Yusuf S.

2024-07-259 citations

10.1016/s0140-6736(24)01050-x

Metabolic, behavioural, and psychosocial risk factors and cardiovascular disease in women compared with men in 21 high-income, middle-income, and low-income countries: an analysis of the PURE study.

Walli-Attaei M, Rosengren A, Rangarajan S, Breet Y, Abdul-Razak S, Sharief WA, Alhabib KF, Avezum A, Chifamba J, Diaz R, Gupta R, Hu B, Iqbal R, Ismail R, Kelishadi R, Khatib R, Lang X, Li S, Lopez-Jaramillo P, Mohan V, Oguz A, Palileo-Villanueva LM, Poltyn-Zaradna K, R SP, Pinnaka LVM, Serón P, Teo K, Verghese ST, Wielgosz A, Yeates K, Yusuf R, Anand SS, Yusuf S, PURE investigators.

2022-09-0198 citations

10.1016/s0140-6736(22)01441-6

Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study

Neeraj Narula, Emily C L Wong, Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan et al. (35 authors)

BMJ2021-07-14342 citations

10.1136/bmj.n1554

Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults.

Pertiwi K, Küpers LK, Geleijnse JM, Zock PL, Wanders AJ, Kruger HS, van Zyl T, Kruger IM, Smuts CM.

2020-06-164 citations

10.1186/s12944-020-01318-3

Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries.

Dehghan M, Mente A, Rangarajan S, Mohan V, Lear S, Swaminathan S, Wielgosz A, Seron P, Avezum A, Lopez-Jaramillo P, Turbide G, Chifamba J, AlHabib KF, Mohammadifard N, Szuba A, Khatib R, Altuntas Y, Liu X, Iqbal R, Rosengren A, Yusuf R, Smuts M, Yusufali A, Li N, Diaz R, Yusoff K, Kaur M, Soman B, Ismail N, Gupta R, Dans A, Sheridan P, Teo K, Anand SS, Yusuf S.

2020-04-0169 citations

10.1093/ajcn/nqz348

O005 Essential Service Standards for Equitable National Cardiovascular CarE for Aboriginal and Torres Strait Islander People – An Exemplar Approach to Closing the Gap

Alex Brown, Rebekah O’Shea, Kathy Mott, Katharine Brown, Tony Lawson et al. (6 authors)

Global Heart2014-03-01

10.1016/j.gheart.2014.03.1225

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

35 Years to 70 Years

Inclusion criteria

* consenting adults between 35-70 years of age

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame	Description
incident cardiovascular disease	mean follow up of 10 years	cardiovascular death, stroke, myocardial infarction, heart failure

Secondary

Measure	Time frame	Description
Incident COPD	mean follow up of 10 years	development of COPD
Incident Asthma	mean follow up of 10 years	development of asthma
Pneumonia	mean follow up of 10 years	hospitalization for pneumonia
Respiratory outcomes	mean follow up of 10 years	change in pulmonary function test
All Cause Hospitalizations	mean follow up of 10 years	All cause hospitalizations
incident cancer	mean follow up of 10 years	total and cause specific cancers
All cause and cause specific mortality	mean follow up of 10 years	death from all causes, and cause specific deaths
incident diabetes	mean follow up of 10 years	development of diabetes
obesity	mean follow up of 10 years	development of obesity, change in BMI
hypertension	mean follow up of 10 years	development of hypertension and changes in blood pressure
incident injuries	mean follow up of 10 years	assessing fatal and non-fatal injuries due road traffic accidents and falls
Kidney disease	mean follow up of 10 years	end stage renal disease, dialysis, transplant, changes in renal function

Countries

Argentina, Bangladesh, Brazil, Canada, Chile, China, Colombia, India, Iran, Kazakhstan, Kyrgyzstan, Malaysia, Pakistan, Palestinian Territories, Peru, Philippines, Poland, Russia, Saudi Arabia, South Africa, Sweden, Tanzania, Turkey (Türkiye), United Arab Emirates, Zimbabwe

Contacts

Primary ContactSumathy Rangarajan, MSc

sumathy.rangarajan@phri.ca905-521-2100

Backup ContactJanette Panhuis, BScN, MBA

janette.panhuis@phri.ca905-521-2100

Outcome results