Local Anesthesia
Conditions
Keywords
articaine, local anesthesia, AMSA
Brief summary
The purpose of this study was to investigate and compare pulpal anesthesia and cardiovascular parameters obtained with 0.6 ml of 4% articaine with epinephrine (1:100.000) for anterior and middle superior alveolar nerve (AMSA) block performed by standard and computer-controlled delivery for maxillary teeth extraction.
Interventions
DRUGComputer controlled 4% articaine delivery by Anaeject
Single dose of 0.6ml 4% articaine with epinephrine (1:100.000) delivered by computer controlled local anesthetic delivery system (Anaeject)
Single dose of 0.6ml 4% articaine with epinephrine (1:100.000) delivered by conventional syringe (carpule syringe).
Sponsors
University of Belgrade
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA 1 * maxillary incisors canines or premolars indicated for extraction due to periapical pathology, root fracture or orthodontic treatment
Exclusion criteria
* allergies to local anesthetic solution ingredients, food and drugs * alcohol and drugs abuse * heavy tobacco smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Success of Pulpal Anesthesia for Central Incisive | after 1 hour | Measured by pulp sensitivity to electrical pulp tester |
| Success of Pulpal Anesthesia for Lateral Incisive | after 1 hour | Measured by pulp sensitivity to electrical pulp tester |
| Success of Pulpal Anesthesia for Canine | after 1 hour | Measured by pulp sensitivity to electrical pulp tester |
| Success of Pulpal Anesthesia for First Premolar | after 1 hour | Measured by pulp sensitivity to electrical pulp tester |
| Success of Pulpal Anesthesia for Second Premolar | after 1 hour | Measured by pulp sensitivity to electrical pulp tester |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Duration Central Incisive | up to 60 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Duration Lateral Incisive | up to 60 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Duration Canine | up to 60 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Duration First Premolar | up to 60 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Duration Second Premolar | up to 60 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Systolic blood pressure | baseline | Measured noninvasively in mm Hg |
| Systolic blood pressure at 5th minute | 5th minute | Measured noninvasively in mm Hg |
| Systolic blood pressure at 10th minute | 10th minute | Measured noninvasively in mm Hg |
| Systolic blood pressure at 15th minute | 15th minute | Measured noninvasively in mm Hg |
| Systolic blood pressure at 30th minute | 30th minute | Measured noninvasively in mm Hg |
| Onset Central Incisive | up to 8 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Diastolic blood pressure at 5th minute | 5th minute | Measured noninvasively in mm Hg |
| Diastolic blood pressure at 10th minute | 10th minute | Measured noninvasively in mm Hg |
| Diastolic blood pressure at 15th minute | 15th minute | Measured noninvasively in mm Hg |
| Diastolic blood pressure at 30th minute | 30th minute | Measured noninvasively in mm Hg |
| Heart rate | baseline | Measured noninvasively in beats per minute |
| Heart rate at 5th minute | 5th minute | Measured noninvasively in beats per minute |
| Heart rate at 10th minute | 10th minute | Measured noninvasively in beats per minute |
| Heart rate at 15th minute | 15th minute | Measured noninvasively in beats per minute |
| Heart rate at 30th minute | 30th minute | Measured noninvasively in beats per minute |
| Diastolic blood pressure | baseline | Measured noninvasively in mm Hg |
| Onset Lateral Incisive | up to 8 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Onset Canine | up to 8 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Onset First Premolar | up to 8 minutes | Measured by pulp sensitivity to electrical pulp tester |
| Onset Second Premolar | up to 8 minutes | Measured by pulp sensitivity to electrical pulp tester |
Countries
Serbia
Outcome results
None listed