Magnetic Resonance Imaging, Neuronal Activity
Conditions
Keywords
Pain, Brain responses, Neuroimaging, fMRI, Burn, Memory
Brief summary
Pain is complex phenomenon misunderstood in spite of medical progress and neurosciences. That's why the relief of chronic pain is only partial for a lot of infection as arthrosis, chronic back pain, headaches or neuropathic pain. Certain situations bring to relive pain sensation. Investigators were interested to former burned. They wonder about somatic memory and unconscious of acute.
Detailed description
It is a comparative and monocentric study. There are two groups. On the one hand, there is the former burned and, on the other hand, healthy volunteers. While they thought to painful memory or not, functional Magnetic Resonance Imaging (fMRI) will be performed. Then, investigators compare two functional Magnetic Resonance Imaging (fMRI). Main objective of this study is link up between brain activity by functional Magnetic Resonance Imaging (fMRI) and acute pain memory.
Interventions
OTHERfMRI
During fMRI, patients and control group will have to thought to seven painful memories, seven emotional memories not painful, seven neutral memories. At every memory there is control test. It is to count backwards.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
Two groups: 20 patients and 20 healthy volunteers
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
For control group: * Affiliated or entitled to a social security * Have signed consent before their participation in the study * Adult women and men french and is right handed * Vision and hearing normal or corrected For former burned: * Affiliated or entitled to a social security * Have signed consent before their participation in the study * Adult women and men french and is right handed * Vision and hearing normal or corrected * Localized burn at the hand or feet onset between 12 and 24 years * Not sequelae painful at the inclusion * Scope and depth of the burn according to classifications CIM 10
Exclusion criteria
For control group: * Any contraindications to pass an fMRI test * Neuropathic pains and psychiatric disorders * Medical history of head injuries * Burn presence For former burned: * Any contraindications to pass an fMRI test * Neuropathic pains and psychiatric disorders * Medical history of head injuries
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BOLD (blood-oxygen-level dependent) signal between painful memories | Months 3 | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test. |
| BOLD (blood-oxygen-level dependent) signal between emotional memories not painful | Months 3 | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test. |
| BOLD (blood-oxygen-level dependent) signal between neutral memories | Months 3 | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test. |
| BOLD (blood-oxygen-level dependent) signal between control test. | Months 3 | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BOLD (blood-oxygen-level dependent) signal between control group for every conditions | Months 3 | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and groups for every conditions: painful memories, emotional memories not painful, neutral memories and control test. |
| BOLD (blood-oxygen-level dependent) signal between patients for every conditions | Months 3 | Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and groups for every conditions: painful memories, emotional memories not painful, neutral memories and control test. |
Countries
France
Outcome results
None listed