Primary Aldosteronism
Conditions
Keywords
Primary aldosteronism, cardiovascular events, cerebrovascular events
Brief summary
We intends to conduct a series of original clinical research about PA, and establish a large cohort of PA and essential hypertension patients with long-term follow-up of cardiovascular events, renal end points etc. We will establish a large sample of blood, urine, adrenal tissue of the subjects, and the genomics,metabonomics, proteomics database, to explore the mechanism of the PA and target organ damage, risk factors, diagnostic methods and biomarkers.
Detailed description
This study will include the subjects of a series of studies on hypertension conducted by our team, including essential hypertension, PA subjects, and establish a large sample database and specimen bank through follow-up and omics analysis.
Interventions
OTHERno intervention
no intervention
Sponsors
Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. hypertensive patients who completed ARR screening and necessary further tests; 2. Voluntary to sign the informed consent.
Exclusion criteria
1. patients with severe cardiac, hepatic or renal dysfunction; 2. suspicious or confirmed other types of secondary hypertension, including Cushing's syndrome, pheochromocytoma and renal artery stenosis et al.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| numbers of patients who develop cardiovascular events | 1-15 years | compare the long-term cardiovascular and cerebrovascular events in patients with primary aldosteronism and essential hypertension |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of new atrial fibrillation | 1-15 years | Compare the occurrence of new atrial fibrillation between patients with primary aldosteronism and essential hypertension |
| The incidence of left ventricular hypertrophy | 1-15 years | Compare the occurrence of left ventricular hypertrophy between patients with primary aldosteronism and essential hypertension |
| the variation of carotid intima-media thickness | 1-15 years | Compare the occurrence of the variation of carotid intima-media thickness between patients with primary aldosteronism and essential hypertension |
| estimated glomerular filtration rate (eGFR) | 1-15 years | Compare the incidence of hypertensive nephropathy between two groups (based on eGFR) |
| quality of life score | 1-15 years | Compare the quality of life between unilateral PA and idiopathic bilateral adrenal hyperplasia by the questionnaire. |
| Cardiovascular risk score | 1-15 years | To investigate what kind of cardiovascular risk score can better predict cardiovascular risk of PA |
| subgroup analysis of cardiovascular events | 1-15 years | Compare the cardiovascular and cerebrovascular risk between unilateral PA and idiopathic bilateral adrenal hyperplasia |
Countries
China
Contacts
Primary ContactQifu Li, phD
Backup ContactShumin Yang, phD
Outcome results
None listed