Catheter-Related Bloodstream Infection (CRBSI) Nos, Intestinal Failure
Conditions
Keywords
intestinal failure, catheter-related bloodstream infections, catheter salvage, recurrent infections, home parenteral support
Brief summary
This is an observational study evaluating a catheter salvage strategy in relation to catheter-related bloodstream infections in patients with chronic intestinal failure dependent on home parenteral support. The study is confined to the period 2002 to 2016.
Detailed description
In chronic intestinal failure patients receiving home parenteral support (HPS), catheter-related bloodstream infections (CRBSIs) frequently results in replacement of their tunneled central venous catheters (CVCs) which may lead to future loss of central venous access. This observational study investigates the consequences of a catheter-salvage-strategy related to CRBSIs according to different causative microorganisms, and short- and long-term risk of recurrence of the CRBSI. The study is based on the Copenhagen Intestinal failure database, which is a web-based database with retrospective data collection performed by reviews of medical charts from all adult intestinal failure patients discharged with home parenteral support from the Department of Medical Gastroenterology, Rigshospitalet.
Interventions
BEHAVIORALcatheter salvage
In each case of catheter-related bloodstream infection the management of the central venous catheter was registred to evaluate the future risk of new infections
Sponsors
Rigshospitalet, Denmark
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* chronic intestinal failure dependent on home parenteral support and enrolled in the Copenhagen Intestinal failure database
Exclusion criteria
* Never discharged on home parenteral support
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| new catheter-related bloodstream infections | 2002 to 2016 | The occurrence of catheter-related bloodstream infection after either catheter salvaged (retained central venous catheter) or replaced central venous catheter (new central venous catheter) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| recurrent catheter-related bloodstream infections | 2002 to 2016 | A recurrent infection was defined as a CRBSI with identical microorganism and antibiogram occurring within 100 days of the previous CRBSI in a salvaged CVC. |
| relapse catheter-related bloodstream infection | 2002 to 2016 | A relapse infection was defined as recrudescence of the same causative microorganisms with identical antibiogram within 30 days of the previous CRBSI in a salvaged CVC. |
| primary salvage rate | 2002 to 2016 | The primary salvage rate was defined by the CVC status at hospital discharge. Because of the database setup and retrospective design of the study, all cases were included regardless of main reason to CVC removal (e.g. septic shock, severe sepsis, concomitant CVC problems and secondary or metastatic complications). |
Countries
Denmark
Outcome results
None listed