Hepatitis B / Liver Space-occupying Lesions / Patients After Ablation
Conditions
Keywords
diagnosis performance, hepatocellular carcinoma, liver fibrosis, progression
Brief summary
Liver diseases are worldwide problems. liver fibrosis and hepatocellular carcinoma are mostly concerned by clinicians. Radiomcis can improve diagnosis accuracy and evaluate disease progression. Hence,investors try to combine radiomics and ultrasound images together in order to improve diagnosis performances of liver fibrosis, benign and malignant tumor and progression after liver ablations.
Detailed description
Liver diseases are worldwide problems including diffuse hepatitis disease and liver space occupying lesions. Hepatitis B virus infection is the most important one among difuse hepatitis disease. There are 240 million people infected with HBV globally, and more than one-third of these patients (approximately 93 million) live in China. For them, a precise estimation of the degree of liver fibrosis is important for estimation of prognosis, surveillance, and treatment decisions in patients with HBV infection. Hepatocellular carcinoma is usually detected in liver space occupying lesions and leading to third common death of cancer. Hence, precise diagnosis between benign and malignant tumor is of great significance. Many guidelines recommend ablation as first line treatment to small hepatocellular carcinoma, especially to those less than 1mm. Liver biopsy has been considered the gold standard for assessing liver diseases. However, it is limited because of sample errors, interobserver variability and many complications, such as pain, bleeding and even death. CT/MR are alternative ways with high cost and complications. Ultrasound was a first optional tool to diagnose liver disease. However, there are still some problems remained to solve:first, the diagnosis accuracy of liver fibrosis remained to be improved. Second,the diagnosis performances for distinguishing benign and malignant tumor were poor. Third, there were not objective way to assess progression after liver ablations. Radiomcis refers to the extraction and analysis of large amounts of image features from medical images. Previous studies showed that it can improve diagnosis accuracy and evaluating disease progression. Hence,we tried to combined radiomics and ultrasound images together in order to improve diagnosis performances of liver fibrosis, benign and malignant tumor and progression after liver ablations.
Interventions
DIAGNOSTIC_TESTradiomics
Sponsors
Third Affiliated Hospital, Sun Yat-Sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
For chronic hepatitis patients to assess liver biopsy Inclusion Criteria: * HBsAg positive or HBV-DNA detected * agreed to undergo liver biopsy * agreed to participated in our study
Exclusion criteria
* combined with other liver disease(eg. HAV/HCV/HDV,alcoholic liver disease) * combined with HIV * combined with malignant liver space occupying lesions * liver transplantation * pregnant * the sample size of liver biopsy could not demand: length lower than 15mm, portal areas less than 6. For patients classified between benign and malignant tumor Inclusion Criteria: * patients diagnosed with liver space occupying lesions * with histology results of liver space occupying lesions. * agreed to participate in our study and signed informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| liver fibrosis | 1 year | the degree of liver fibrosis |
| benign or malignance | 5 years | the malignance of liver space occupying lesions |
| The incidence of recurrence | 5 years | the incidence of liver cancer recurrence after ablation |
Countries
China
Outcome results
None listed