Keratectasia, Keratoconus, Pellucid Marginal Corneal Degeneration
Conditions
Brief summary
The purpose of this research study is to find out if the new Brillouin Ocular Scanner can measure the variation (difference) of the corneal elastic changes involved in the onset of corneal ectasia, induced by LASIK surgery and cornea collagen crosslinking (CXL) treatment. Ectasia refers to the thinning and bulging of the cornea and results in severe vision degradation (loss), which may occur because of a progressive disease (keratoconus) or because of LASIK surgery. It is believed that the structural weakening of the cornea plays a major role in developing ectasia. CXL is a treatment that is able to halt the progression of ectasia. The Brillouin Ocular Scanner is a technique based on the principles used in the laser speed measuring of a car (radar gun). When laser light illuminates a moving sample, a portion of the light slightly changes color. In our body, e.g in eye and corneal tissue, very weak sound waves are naturally present and they can induce a similar color shift. Measuring this color shift with a sensitive light color meter (spectrometer), we will measure the sound speed in the tissue.
Interventions
DEVICEBrillouin Ocular Scanner
Sponsors
Massachusetts Eye and Ear Infirmary
Massachusetts General Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects with healthy cornea * Patients with mild, moderate, or advanced keratoconus * Subjects diagnosed with PMD * Patients before and after LASK surgery * Patients with keratoconus before and after collagen crosslinking treatment
Exclusion criteria
* Normal volunteer group: presbyopia and/or cataract * Keratoconus subjects group: corneas with scars developed, received any ocular surgery, such as laser vision correction surgeries or CXL treatment * Subjects diagnosed with PMD: excludes corneas received any ocular surgery, such as laser vision correction or CXL treatment * Patients before and after LASK surgery Corneas received priori ocular surgeries, taking any ocular medications except season allergy medicine such as artificial tears
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brillouin frequency shift of corneal stroma | at time of measurement | Brillouin frequency shift of corneal stroma in normal corneas and corneas diagnosed with keratoconus and pellucid marginal degeneration |
| Change of Brillouin frequency shift from base line in corneas received LASIK surgery | 1 day and 4-8 weeks | Brillouin frequency shift in corneas before and after receiving LASIK surgery |
| Change of Brillouin frequency shift from base line in corneas received crosslinking treatment | 3 days, 1 month, 3 months, 6 months | Brillouin frequency shift in corneas before and after receiving crosslinking surgery |
Countries
Switzerland, United States
Outcome results
None listed