Healthy
Conditions
Brief summary
The purpose of our graduate student research study is to observe the effects of ginger on hsCRP, IL-6, and TNF-α levels in exercising individuals based on their level of activity.
Detailed description
Participants will fill out a demographic questionnaire and a quality of life survey, (SF-36). Take a 3g supplement of ginger in powder form with meals once/day (preferably in the morning) for 8 weeks. By end of week 4 (halfway through the study), subjects will do another blood test for mid-intervention CRP, IL-6, and TNF-α values. By end of week 8, participants will do a final blood test for CRP values and fill out the SF-36 survey for post-intervention levels.
Interventions
DIETARY_SUPPLEMENTGinger
3g ginger powder supplement once a day with meals (preferably in the morning) for a duration of 8 weeks. Powder can be mixed with juice or water.
Sponsors
Loma Linda University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* 30 - 70 years of age * Various levels of activity outlined by the General Physical Activities Defined by Level of Intensity by the American College of Sports Medicine (ACSM) and the Centers for Disease Control and Prevention (CDC). * Regular Exercisers- at least 30 minutes of moderate to vigorous activity at least 3 times per week. * Non-regular Exercisers- at least 30 minutes of moderate to vigorous activity 1-2 times per week.
Exclusion criteria
* Individuals currently taking... * Vit D * Aspirin * Coumadin * Ginger supplements more than 1x/week within the last month * Heparin * NSAIDs * Pain meds * Individuals with chronic inflammatory conditions such as Cancer, CVD, Diabetes, Gastroesophageal reflux disease (GERD), Ginger allergies, Metabolic Syndrome, and/or autoimmune diseases such as Rheumatoid Arthritis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SF-36 Questionnaire | Change from baseline to end of 8 weeks. | Quality of life will be assessed using the 36-item Short Form Survey Instrument (SF-36). It was developed by the RAND corporation. The SF-36 is a well accepted and valid survey used to assess overall health measuring 8 different dimensions including physical and social functionality and limitations, mental health, vitality, pain, general health perception, and health change.20 It is a self-administered survey that takes about 10 minutes to complete. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory Bio Markers | A composite measurement from :1) at baseline 2) mid point (at 4weeks) and at 3) end of 8 weeks. | Inflammation will be measured using the biomarkers Interleukin-6 (IL-6), Tumor Necrosis Factor Alpha (TNF-α), and C-reactive Protein (CRP) using a venipuncture blood draw. Venous blood will be drawn from the antecubital vein using a standard venipuncture protocol for a total of 8 mL or 0.5 tablespoons of blood. |
Countries
United States
Outcome results
None listed