Fractures, Bone, Bone Marrow Disease, Fat Disorder, Adiposity
Conditions
Keywords
marrow adipose tissue, bone marrow adiposity
Brief summary
The purpose is to determine in a case-control study if an association exist between bone marrow adiposity and fragility fractures in post-menopausal women.
Interventions
DEVICEDixon Magnetic Resonance Imaging
MRI of the lumbar spine (L1 to L4) and hip (non-dominant) for the measurement of Ad Med. (In%) by the DIXON sequence.
Subjects will undergo DXA scan to assess total body (less head) and lumbar spine bone mineral density.
Sponsors
University Hospital, Lille
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* post-menopausal women : 50-90 years old * Group 1 (cases) : occurence of incident major osteoporotic fracture less than 12 months * Group 2 (controls) : no history of fragility fracture
Exclusion criteria
* Implants that are contraindicated for the magnetic resonance (MR) examination. * Implants that might create a health risk or other problem during an MR exam include: 1) cardiac pacemaker or implantable defibrillator, 2) catheter that has metal components that may pose a risk of a burn injury, 3) a ferromagnetic metal clip placed to prevent bleeding from an intracranial aneurysm, 4) an implanted medication pump (such as that used to deliver insulin or a pain-relieving drug), and 5) a cochlear implant. * body mass index \[BMI\] \>38 kg/m2, weight \>140 kg * Disease or current use of medications known to affect bone density, including oral glucocorticoids, treatments for osteoporosis (bisphosphonates, raloxifene, calcitonin, or PTH), hormone therapy. * Chronic kidney disease with DFG \<30 ml/mn
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone marrow fat content at lumbar spine | 24 months | Total bone marrow fat content (percentage) at lumbar spine (L1-L4) measured with magnetic resonance imaging |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bone marrow fat content at total hip | 24 months | Total bone marrow fat content (percentage) at total hip measured with magnetic resonance imaging |
| Bone mineral density at lumbar spine | 24 months | Bone mineral density (g/cm2) at lumbar spine (L1-L4) measured by DXA |
| Bone mineral density at total hip | 24 months | Bone mineral density (g/cm2) at total hip measured by DXA |
Countries
France
Outcome results
None listed